Postdoct in soft matter chemistry/physics in biomolecular condensates (H/F)

Research Center

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Curie Institute

Curie Institute is a major player in research and the fight against cancer. It consists of a hospital and a Research Center with more than 1,000 employees with strong international representation. The objective of the Research Center of the Curie Institute is to rely on fundamental research and to use the knowledge produced to improve the diagnosis, prognosis, and therapy of cancers within the framework of a continuum between fundamental research and innovation, at the service of the patient.

Laboratory

Research Unit : Physics of Cells and Cancer (UMR168)

Unit Director : Pascal Hersen

Team : Molecular Microscopy of Membranes (https://curie.fr/equipe/levy)

Location : Pavillon Curie, 11 Rue Pierre et Marie Curie, 75005 Paris, France

Research Project

Liquid-liquid phase separation (LLPS) of intracellular macromolecules is one of the principles used for cell compartmentalization. Misregulation of LLPS processes can cause transformation of LLPS droplets into other physical states such as gels or fibrils, some of which, e.g. amyloids, can lead to neurodegenerative diseases and other pathologies. The project aims to investigate in vitro physicochemical properties of these liquid condensates to understand their life cycle and possible mechanisms of transformation into amyloid fibrils. We will focus on the role of interfaces between the condensate and its environment on the reactivity and dynamics of the condensates. The project employs a multidisciplinary approach combining physical chemistry, soft matter physics, state-of-the-art cryo-electron microscopy (Cryo-EM), and microfluidics. The project will be developed in close collaboration with an onsite biochemistry facility for protein production, as well as with the group of Dr. Stephanie Descroix (PCC) for microfluidics. Cryo-EM will be supported by the strong expertise of the host team. The project is financed by university PSL «PSL Young Researcher Starting Grant».

Candidate profile

- PhD in chemistry or physics, or a related field relevant to the subject matter

- Preferably, the applicant possesses prior experience in one or more of the following areas: soft matter, thermodynamics of polymers, protein chemistry, molecular-scale structural analysis (Cryo-EM or cyclotron experiments), spectroscopies, microfluidics.

- Good communication skill in English is required.

Merci de déposer les documents CV comprenant au moins deux coordonnées de référence et une lettre de motivation avec votre Nom

Informations sur le contrat

Contract type : Fixed-term contract

Start date : as soon as possible

Contract duration : 18 months

Working hours : Full-time

Salary : according to current pay grids

Benefits : International research environment located at the Paris center and surrounded by other high-level research institutes (ex. ENS, ESPCI and College de France), reimbursement of public transportation fees up to 70%, supplementary health insurance, canteen.

Location : Paris

Reference : NA

Contact

How to apply: Please send a cover letter (briefly explaining the motivation, background, and main achievements) and a complete CV including at least two references

Application deadline: once the position is filled

Date de parution de l’offre : 07 Nov 2024

Institut Curie is an inclusive, equal opportunity employer

and is dedicated to the highest standards of research integrity.

https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf