Assistant Engineer (AI) in cell biology (M/F)

Laboratoire - Service

The candidate will work in the Biology of Centrosomes and Genetic Instability group led by Renata BASTO (Institut Curie, Paris 5, https://institut-curie.org/team/basto). The team has extensive expertise in the field of cell division  and studies the molecular mechanisms underlying genetic and chromosomal instability. Various model systems are used in the laby, including mouse models, Drosophila, and cultured human cells, providing a complementary range of approaches and expertise.

Missions  

The candidate will work with the team members on various cell biology projects related to genetic instability to uncover the principles governing cell proliferation during development and to determine how genetic instability contributes to the early stages of disease.

We are looking for an AI interested in questions related to chromosome segregation and polyploidy in both healthy and tumor contexts. The candidate will work with cultured cell lines, Drosophila, and mouse models.

Description of lab tasks

-          Cell culture, generation of cell lines by lentiviral infection, treatment with pharmacological tools

-          Isolation, culture, and characterization of murine stem cells

-          Sorting and analyzing cell populations by flow cytometry

-          Drosophila cultures

-          Immunofluorescences techniques on cells and tissues

-          Wide-field and confocal microscopy on fixed and live samples

-          Molecular biology (DNA/RNA extraction, cloning)

-          Data analysis and maintenance of the laboratory notebook

-          Presentation of results

Training and experience required

-          Licence degree ( or equivalent to Bac+3)

-          Experience in microscopy is recommended but not mandatory

-          Experience in cell culture is recommended but not mandatory

          Skills required

-          Ability to work in a team, motivation, and autonomy

-          Professional English (required)

-          Computer skills (recommended: image analysis using Fiji)

All our opportunities are open to people with disabilities

Type of contract: Fixed-term contract

Start date as soon as possible

Contract duration: 18 months

Working hours: Full time - 39 hours/week

Remuneration: in accordance with current pay scales

Benefits: Collective catering, 70% reimbursement of annual travel expenses, company health insurance scheme.

Job location: Paris 5th arrondissement

Reference : NA

Contact

To apply, please send CV and covering letter

Posting date: 22sd of August 2024

Deadline for applications: when the position is filled.

The Institut Curie is an inclusive equal opportunities employer.

It is also committed to high standards of research integrity.

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