Bioinformatics at Chromatin & Splicing team (M/F)

Date de clôture
Lieu(x) de travail
Orsay
Secteur
Centre de Recherche
CDD
The Institut Curie Research Center
Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital Group and a Research Center of more than 1000 employees with a strong international representativeness.
The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Job description

  • Laboratory:

Chromatin & Splicing team at the Genome Integrity, RNA and Cancer unit

Our team aims at deciphering the role of histone modifications and histone variants in pre-mRNA alternative splicing regulation. Alternative splicing is an RNA process in which different mature mRNAs can be obtained from the same pre-mRNA sequence, increasing like this the protein diversity and capacity of a cell to gain new phenotypic traits.

In the past 20 years, chromatin has been shown to play an important role in this highly regulated process, although the mechanisms are not entirely known yet. Using available and soon to be developed genome-wide transcriptomics and epigenomics data, we are looking for splicing signatures dependent on chromatin modifications to elucidate the functional role of these marks in splicing regulation. Different human and mouse models will be used in collaboration with leaders in the chromatin, splicing and cancer fields.

For more details visit our website: https://institut-curie.org/team/luco

 

  • Missions
    • Analyze RNA-seq data to identify changes in gene expression and alternative splicing in different human and mouse models
    • Analyze ChIP-seq and CUT&RUN epigenomic data
    • Integrate genome-wide data to identify splicing-associated histone marks
    • Integrate CLIP-seq and RIP-seq data to identify RNA binding sites
    • Perform RNA and DNA motif search analysis
    • Analyze TCGA breast cancer data.

 

 

 

Candidate Profile

  • Training and experience required
    • Master or PhD, preferably in Data Science, Bioinformatics or related fields.
  • Skills required
    • Solid skillset for handling NGS datasets and expertise in developing analysis pipelines
    • The candidate will need to be autonomous and resourceful with experience in programming and knowledge in biostatistics.
    • Strong interest in life sciences.
    • Basic knowledge in biology (namely chromatin, transcription, splicing) will be an advantage.
    • Ability to collaborate with “wet bench” researchers.

 

All our opportunities are open to people with disabilities

 

 

Contract information

  • Type of contract: Fixed-term contract
  • Starting date:  October 2022
  • Duration: 18 months (renewable another 18 months)
  • Working time: Full time - 39 hours per week
  • Remuneration: According to the current grids
  • Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance
  • Location of the position: Orsay
  • Reference: 2022-08-3348-BIOINF01

 

 

Contact

Please send your CV, letter of motivation and 2 references, to Reini Luco at reini.luco@curie.fr

 

Publication date: August 2022

Deadline for application: September 2022

 

Institut Curie is an inclusive, equal opportunity employer

and is dedicated to the highest standards of research integrity.

 

Exemple : +33112365489
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