Post-doctoral/Research engineer - Super-Resolution imaging (M/F)
Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital Group and a Research Center of more than 1000 employees with a strong international representativeness.
The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.
- Directeur(s) de thèse : Geneviève Almouzni
- Equipe : Dynamique de la Chromatine
- Unité : UMR3664 - Dynamique du noyau
The Chromatin Dynamics Team (UMR 3664-CNRS) led by Dr G. Almouzni explores how chromatin organization from its elementary bricks (histone variants and nucleosomes) up to chromosomal landmarks and nuclear architecture functionally impacts/ adapts to cell physiology https://institut-curie.org/team/almouzni).
We aim to define the control of the molecular interactions between histone chaperones and histone variants and how they act as a flexible network to assemble, maintain or change chromatin states during normal (development, differentiation) and pathological (cancer) changes of cell fate. We combine various biological models from cells to tissue with experimental approaches involving biochemistry, imaging and omics.
Objective will be to characterize at the single molecule resolution the localization of histone variants and chromatin regulators in live and fixed nuclei of cells undergoing changes of fate and DNA transaction events such as replication, transcription, repair. In these physiological contexts, dynamics and spatial organization of chromosomal loci and euchromatin/heterochromatin domains will be investigated.
Motivated Candidate should be trained in cell biology and demonstrate expertise in cell culture that must include ES cells / 3D cell culture (organoids/embryoids). Know-how of sample preparation and acquisition of Super-Resolution images is mandatory. Additional experience with data processing for image rendering and physical parameters s will be highly appreciated.
Successful candidate will join an experienced team composed of staff scientists, post-doctoral researchers and students in a vibrant international scientific community at the Institut Curie in Paris. Access to multidisciplinary approaches, new technologies and advanced training programs as well as career development and networking opportunities is provided.
All our opportunities are open to people with disabilities.
- Type of contract: CDD
- Starting date: As soon as possible
- Duration: 2 years (renewable contract)
- Working time: Full time
- Remuneration: According to the current grids at Institut Curie
- Avantages: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance
- Localisation of the position: Paris
- Reference: 2023-02-UMR3664-SRimaging01
Please send cover letter, CV and recommendations to email@example.com.
Publication date: 02/21/2023
Deadline for application: 03/31/2023
Institut Curie is an inclusive, equal opportunity employer
and is dedicated to the highest standards of research integrity.