The Genomics and Development of Childhood Cancers lab (https://institut-curie.org/team/saulnier), headed by Olivier Saulnier, is looking for one postdoctoral researcher in bioinformatics on cancer genomics.
Our team focuses on using cutting-edge high-throughput genomic approaches and genome-wide data analyses to study the spatio-temporal origins of pediatric brain tumors. In addition, we investigate the transcriptional and post-transcriptional programs of the normal development that are hijacked by cancer cells in order to exploit these vulnerabilities as new therapeutic strategies. We are located in the heart of Paris at Institut Curie, one of the world’s leading institutions in cancer research. It represents an excellent and international environment with interdisciplinary expertise and high-quality technological platforms.
The aim of the project is to investigate transcriptional and post-transcriptional signatures of pediatric cancers. The successful candidate will use high-throughput single cell data of tumor cells as well as normal human development.
1/ Hendrikse*, Haldipur*, Saulnier*, et al., Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature. 2022
2/ Vibert*, Saulnier*, et al., Oncogenic chimeric transcription factors drive tumor-specific transcription, processing, and translation of silent genomic regions. Molecular Cell. 2022
3/ Saulnier*, Guedri-Idjouadiene*, et al., ERG transcription factors have a splicing regulatory function involving RBFOX2 that is altered in the EWS-FLI1 oncogenic fusion. Nucleic Acids Research 2021
Training and experience required
- Training: Applicant should hold, or be in the process of completing, a PhD degree in bioinformatics or related areas
- Scientific skills: should have solid computational skills, and a strong interest in cancer biology, genomics and/or developmental biology
- Professional experience desirable: experience with single-cell omics
- Language skills: very good English level and communication skills
- Ability to work independently, to communicate and to work in a team
- The candidate should be highly motivated, curious, and enthusiastic to work in a collaborative team.
All our opportunities are open to people with disabilities.
- Type of contract: Fixed-term contract
- Starting date: As soon as possible
- Duration: 1 year (renewable)
- Working time: full time
- Remuneration: according to the current grids
- Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance
- Location of the position: Paris
- Reference: 2023-11-U830-BIOINF01
Please send a CV with a list of publications, a motivation letter including past research and career goals, and contact information of at least two references to firstname.lastname@example.org.
Applications will be reviewed as received.
Publication date: November 17th, 2023
Deadline for application: December 31st, 2023
Institut Curie is an inclusive, equal opportunity employer
and is dedicated to the highest standards of research integrity.