Postdoctoral Position in Immunology (aging, macrophages, lung cancer) (M/F)
Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international representativeness.
The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.
- Nicolas Manel Laboratory at Institut Curie
Nicolas Manel Lab website: http://minilien.curie.fr/ejggfa
Aging is the first risk factor for lung cancer and is characterized by a gradual dysfunction of the immune system. How cellular mechanisms of aging in the immune system control the progression and therapy of lung cancer is largely unknown. Our lab has recently discovered a novel mechanism of aging, which leads to acquisition of hallmarks of senescence in alveolar macrophages (AMs). By investigating mouse models, we found that Lamin A/C protects lung AMs from nuclear envelope rupture, genome instability and hallmarks of aging. Lung tumors develop faster in mice deficient for Lamin A/C in immune cells. Aging markers of AMs are detected in human lung cancer samples.
- The project
The post-doctoral researcher will study how macrophages play contribute to lung cancer and immunotherapy during aging. One project is available based on in vivo mouse models (Project 1). Another project is available based on human samples from patient cohorts (Project 2). Both projects will benefit from state-of-the single-cell and spatial omics approaches. The positions are part of a 5-year collaborative project funded the ARC Foundation. This project is a collaboration with the teams of Nicolas Girard (clinician, lung cancer), Hélène Salmon (tumor fibroblasts) and Xavier Paoletti (statistics).
Selective STING stimulation in dendritic cells primes antitumor T cell response. Science Immunology. 2023.
Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages. bioRxiv. 2022.
Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer. NEJM. 2022.
Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors. Cancer Discovery. 2022.
Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion. Cell. 2021.
NONO detects the nuclear HIV capsid to promote cGAS-mediated innate immune activation. Cell. 2018
Transmission of Innate Immune Signaling by Packaging of cGAMP in Viral Particles. Science. 2015.
- Candidate Profile
Training and Skills required
- Training: PhD in Biology, Immunology, Aging or Cancer
- Scientific skills: Cytometry, analysis of gene expression
- Professional experience desirable: academic experience in EITHER mouse immunology (Project 1) OR human immunology (Project 2)
- Language skills: English
- Ability to work independently, managerial abilities, aptitude for working in a team
- Ability to communicate in English
All our opportunities are open to people with disabilities
- Contract information
Type of contract: Fixed-term contract.
Starting date: flexible
Duration: 3 years
Working time: full time
Remuneration: according to the current grids
Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance
Location of the position: Paris, 75005
To apply: submit a cover letter containing a statement of interests and future goals, a CV with a list of publications and contact information for two references to email@example.com.
Publication date: 16/03/2023
Deadline for application: 15/06/2023