Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital Group and a Research Center of more than 1000 employees with a strong international representativeness.
The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.
The Stem cell immunity laboratory is a young and dynamic team, created in the Institut Curie in December 2021 within the Immunity and Cancer unit (U932). Because stem cells are key for the maintenance of tissue architecture and integrity, they need to be protected from insults. There is increasing evidence that stem cells implement specific immune mechanisms not found in differentiated cells. The team focuses on identifying and characterising these mechanisms. For example, we recently discovered that stem cells express an antiviral protein called aviD, which specifically targets viral genomes and thwarts infection from RNA viruses such as SARS-CoV-2 (Poirier et al., 2021, Science).
Our current projects focus on:
- understanding and characterising the aviD antiviral response
- assessing if stem cell-specific mechanisms of protection are shared by cancer cells and play a role in cancer growth or immune evasion
- discovering novel stem cell-specific mechanisms of defence
We are looking for a highly motivated research engineer to join the team. He/She will be involved in conducting a research project centred on identifying novel antiviral pathways in stem cells.
Stem cells are shielded from viruses by multiple, unrelated pathways which can be viewed as different “layers” of protection. For example, they express interferon stimulated genes at steady state (1, 2), as well as the antiviral protein aviD (3). Because of their cornerstone role in tissue integrity, we hypothesise that additional, unknown antiviral mechanisms exist in stem cells. The aim of this project is to implement unbiased screening approaches to identify such protective pathways and characterise them in cell culture and in vivo.
1. X. Wu et al., Cell (2017), doi:10.1016/j.cell.2017.11.018.
2. P. V. Maillard, A. G. Veen, E. Z. Poirier, C. Reis e Sousa, EMBO J. 38 (2019), doi:10.15252/embj.2018100941.
3. E. Z. Poirier et al., Science. 373, 231–236 (2021).
- Training and experience required
- BAC+5 (Master in Biology).
- Professional experience will be considered favourably
- Skills required
- Basic experimental techniques in cellular and molecular biology (nucleic acid and protein manipulation, cell culture)
- Knowledge of virus models is not necessary but will be considered favourably
All our opportunities are open to people with disabilities
- Type of contract: Fixed-term contract
- Starting date: January 2022
- Duration: 18 months, renewable
- Working time: full time
- Remuneration: according to the current grids
- Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance
- Location of the position: Paris
- Reference: 2021-11-INGPOIR932
Please send your CV, letter of motivation and 2 references, to Enzo Poirier (email@example.com)
Publication date: 02/11/2021
Deadline for application: 01/12/2021