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MARIA DA GRACA RAPOSO

Research Director CNRS
Recherche - Paris
Spécialités / domaines
Cell biology,
Cancer,
Dermatologie,
Cellular and Tissue Imaging,
Electronic microscopy
Functions within Institut Curie:
Présentation

G. Raposo received her PhD in 1989 at the Univ. Paris VII (Université de Paris) . Her work focused on the intracellular trafficking of neurotransmittor receptors exploiting imaging and in particular she gained expertise in electron microscopy. From 1990 to 1995 she was a post-doc in the Immunology Center, Marseille, where she started studying the trafficking of MHC class II molecules. Because of her expertise in EM she pursued studies in immune cells  in the Dept of Cell Biology, Utrecht University, The Netherlands. While in the team of Hans Geuze she showed that B lymphocytes secrete exosomes with antigen presentation capacities leading her to pursue on understanding main cell biological principles of the generation and function of Exosomes and other ExtracellularVesicles .  Since 1995 she is a team leader in the Dept of Cell Biology and Cancer. In the past 8 years she  took in charge the Direction  of the Training unit at Institut Curie. Her current research focus is on the biogenesis and functions of Extracellular Vesicles and lysosome related organelles, with a focus on pigment granules, with implications in disease. Distinctions : CNRS Silver Medal, Descartes Huygens Price, Royal Dutch Academy, ISEV achievement award, Raymond Castaing Price from the society for Microscopies and EMBO member since 2015.

 

Publications
Human Cytomegalovirus Infection Changes the Pattern of Surface Markers of Small Extracellular Vesicles Isolated From First Trimester Placental Long-Term Histocultures
Frontiers in Cell and Developmental Biology
Mathilde Bergamelli, Hélène Martin, Mélinda Bénard, Jérôme Ausseil, Jean-Michel Mansuy, Ilse Hurbain, Maïlys Mouysset, Marion Groussolles, Géraldine Cartron, Yann Tanguy le Gac, Nathalie Moinard, Elsa Suberbielle, Jacques Izopet, Charlotte Tscherning, Graça Raposo, Daniel Gonzalez-Dunia, Gisela D’Angelo, Cécile E. Malnou
The power of imaging to understand extracellular vesicle biology in vivo
Nature Methods
Frederik J. Verweij, Leonora Balaj, Chantal M. Boulanger, David R. F. Carter, Ewoud B. Compeer, Gisela D’Angelo, Samir El Andaloussi, Jacky G. Goetz, Julia Christina Gross, Vincent Hyenne, Eva-Maria Krämer-Albers, Charles P. Lai, Xavier Loyer, Alex Marki, Stefan Momma, Esther N. M. Nolte-‘t Hoen, D. Michiel Pegtel, Hector Peinado, Graça Raposo, Kirsi Rilla, Hidetoshi Tahara, Clotilde Théry, Martin E. van Royen, Roosmarijn E. Vandenbroucke, Ann M. Wehman, Kenneth Witwer, Zhiwei Wu, Richard Wubbolts, Guillaume van Niel
HPM live μ for a full CLEM workflow
Methods in Cell Biology
Xavier Heiligenstein, Marit de Beer, Jérôme Heiligenstein, Frédérique Eyraud, Laurent Manet, Fabrice Schmitt, Edwin Lamers, Joerg Lindenau, Mariska Kea-te Lindert, Jean Salamero, Graça Raposo, Nico Sommerdijk, Martin Belle, Anat Akiva