World Triple Negative Breast Cancer Day, held on March 3rd, is a reminder that triple-negative breast cancers remain the most difficult to treat, and that only innovation and dynamic research can bring hope of curing more patients.At Institut Curie, Europe's leading breast cancer treatment center[1], with its recognized expertise in fundamental, translational, and clinical research, several innovative trials are underway to develop new treatments and detect relapse at an early stage. These trials are part of the IHU "Institut des cancers des femmes" project founded by Institut Curie with PSL and Inserm.