FRANCK TOLEDO

Professor,

Professor Sorbonne University

Recherche - Paris

Spécialités / domaines

Development, cancer, genetics and epigenetics

Functions within Institut Curie:

Team Leader

Genetics of Tumor Suppression
Unit : Dynamics of Genetic Information: fundamental bases and cancer (DIG-Cancer) (UMR3244)

Présentation

Team Leader, Genetics of Tumor Suppression Team (since April 2007).

Centers of interest / expertise: p53, MDM4, DREAM complex, telomeres, bone marrrow failure syndromes

ORCID # 000-0003-3798-4106

Publications

2023

p53 in the Molecular Circuitry of Bone Marrow Failure Syndromes

International Journal of Molecular Sciences

Jeanne Rakotopare, Franck Toledo

(2023 06 Oct)

2023

A systematic approach identifies p53-DREAM pathway target genes associated with blood or brain abnormalities

Disease Models & Mechanisms

2020

Mechanisms Generating Cancer Genome Complexity: Back to the Future

Cancers

Franck Toledo

(2020 15 Dec)

2020

Germline mutation of MDM4, a major p53 regulator, in a familial syndrome of defective telomere maintenance

Science Advances

Eléonore Toufektchan, Vincent Lejour, Romane Durand, Neelam Giri, Irena Draskovic, Boris Bardot, Pierre Laplante, Sara Jaber, Blanche P. Alter, José-Arturo Londono-Vallejo, Sharon A. Savage, Franck Toledo

(2020 10 Apr)

2018

The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure

Cancers

Eléonore Toufektchan, Franck Toledo

(2018 06 May)

2017

Essential role for centromeric factors following p53 loss and oncogenic transformation

Genes & Development

Dan Filipescu, Monica Naughtin, Katrina Podsypanina, Vincent Lejour, Laurence Wilson, Zachary A. Gurard-Levin, Guillermo A. Orsi, Iva Simeonova, Eleonore Toufektchan, Laura D. Attardi, Franck Toledo, Geneviève Almouzni

(2017 01 Mar)

2017

Targeting MDM4 Splicing in Cancers

Genes

Boris Bardot, Franck Toledo

(2017 20 Feb)

2017

Les liaisons dangereuses : p53, dyskératose congénitale et anémie de Fanconi

médecine/sciences

Eléonore Toufektchan, Sara Jaber, Franck Toledo

(2017 01 Jan)

2016

p53: A two-faced regulator of telomere metabolism? (comment on DOI 10.1002/bies.201600078)

BioEssays

Franck Toledo

(2016 01 Oct)

2016

p53 downregulates the Fanconi anaemia DNA repair pathway

Nature Communications

Sara Jaber, Eléonore Toufektchan, Vincent Lejour, Boris Bardot, Franck Toledo

(2016 01 Apr)