Unit
Dynamics of Genetic Information: fundamental bases and cancer (DIG-Cancer) (UMR3244)
Thematic areas of research:
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ANTONIN MORILLON / VALERIE BORDE
Dynamics of Genetic Information: fundamental bases and cancer (DIG-Cancer) (UMR3244)
The teams in this unit aim to better understand the mechanisms that maintain genome and epigenome integrity and expression and study how disruptions in these processes contribute to cancers and age-related human diseases.
Teams
Key figures
123
Publications since 2019
4
ERC since 2019
3
Spin-off since 2019
Key publications
All publications
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Multi-modal quantification of pathway activity with MAYANature Communications
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Kronos scRT: a uniform framework for single-cell replication timing analysisNature Communications
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Molecular basis of the dual role of the Mlh1-Mlh3 endonuclease in MMR and in meiotic crossover formationProceedings of the National Academy of Sciences
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Interactive analysis of single-cell epigenomic landscapes with ChromSCapeNature Communications
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News
All news
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L’Institut Curie engagé sur le front des cancers masculinsEn novembre, mois de sensibilisation aux cancers masculins, l’Institut Curie met en lumière les spécificités de ces cancers. Ses trois sites, Paris, Saint-Cloud et Orsay, offrent à chaque patient une prise en charge optimale des cancers de la prostate, des testicules et du pénis, ainsi qu’un accès à l’innovation. Côté recherche, les équipes s’intéressent aux aspects biologiques et physiologiques de ces maladies.03/11/2023 -
Institut Curie’s latest progress at the AACR Annual Meeting 2023From April 14 to 19, 2023, in Orlando, USA, the international scientific and medical community comes together for the annual meeting of the American Association for Cancer Research, an opportunity for scientists from Institut Curie to present their findings in various fields of cancer research.17/04/2023 -
Institut Curie certified as Integrated cancer research site for the third timeFollowing a call for applications launched in April 2022, Institut Curie had its integrated cancer research site project certified by France’s Institut national du cancer (Inca). Its goal is to better understand tumor recurrences in order to better prevent, detect and treat them.20/02/2023 -
Unprecedented: a team from Institut Curie discovers how DNA unzips at the time of replicationAn article published in Cell and co-authored by Chunlong Chen, head of the Replication program and genome instability team at Institut Curie, reports an unprecedented discovery on DNA replication. It helps us better understand how life is created and gives hope for progress in oncology.
Since the discovery of the structure of the double DNA helix in 1953, the way in which double09/01/2023 -
Chunlong Chen, first Institut Curie’s recipient of the Fondation Bettencourt Schueller Impulscience program.The Fondation Bettencourt Schueller has chosen the research project of Chunlong Chen, group leader at Institut Curie Research Center, as one of seven recipients of its new research support program, Impulscience. This funding should allow him to extend his work in fundamental biology on the regulation of DNA replication, as well as genome transcription.28/11/2022 -
L’Institut Curie mobilisé contre les cancers masculinsEn novembre, mois de sensibilisation aux cancers masculins, l’Institut Curie met en lumière sa forte implication dans le diagnostic, le traitement et la recherche sur les cancers de la prostate et des testicules. Les équipes de l'Institut sont sur le front pour prodiguer aux patients la meilleure prise en charge et développer les traitements de demain.14/11/2022
Scientific events
All scientific events
26 Jun
2023
Seminar
11h-12h
A role of a new RAD51/DMC1 remodeler in mammalian recombination
Regulation of Mre11 nuclease activity through Rad50 and its function in DSB repair and meiotic crossover formation
23 Nov
2022
Seminar
09h-23h
Overcoming experimental and computational limitations of multiplexed imaging to study viral infections
Recent technological advances in imaging now allow to simultaneously measure dozens to
hundreds of proteins, either using successive rounds of standard IF imaging or using heavy-metal conjugated antibodies. This has enabled deep spatial characterization of various healthy and diseased tissues, ranging from healthy human kidney to human breast cancer, thus providing a wealth of knowledge. Howeve
hundreds of proteins, either using successive rounds of standard IF imaging or using heavy-metal conjugated antibodies. This has enabled deep spatial characterization of various healthy and diseased tissues, ranging from healthy human kidney to human breast cancer, thus providing a wealth of knowledge. Howeve
21 Oct
2022
Seminar
11h-23h
Molecular mechanisms of evolutionary innovation
Where do genes come from? All genomes contain genes whose sequences appear unique to a given species or lineage to the exclusion of all others. These “orphan” genes cannot be related to any known gene family; they are considered evolutionarily novel and are thought to mediate species-specific traits and adaptations. In this seminar, I will present an investigation of the evolutionary o
1 Apr
2022
Seminar
11h-23h
Functions of biomolecular condensates assembled in response to DNA damage
DNA repair mechanisms are crucial for organismal health and survival. All living organisms have evolved a multitude of mechanisms to repair alterations in the primary structure of DNA. DNA damage response (DDR) proteins often accumulate in nuclear foci seemingly similar to biomolecular condensates, but the intrinsic molecular organization and the functions that arise specifically from the assembly
21 Jan
2022
Seminar
11h-23h
The role of lncRNAs in cancer
The human genome is pervasively transcribed, producing a highly complex transcriptome including thousands of so-called long non-coding RNAs (lncRNAs). Expression of these lncRNAs is deregulated in virtually all cancer types and mechanistic studies suggest they act as regulators of various biological processes or signaling cascades. Together with their often tissue restricted expression,