Unit
Dynamics of Genetic Information: fundamental bases and cancer (DIG-Cancer) (UMR3244)
Thematic areas of research:
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ANTONIN MORILLON / VALERIE BORDE
Dynamics of Genetic Information: fundamental bases and cancer (DIG-Cancer) (UMR3244)
The teams in this unit aim to better understand the mechanisms that maintain genome and epigenome integrity and expression and study how disruptions in these processes contribute to cancers and age-related human diseases.
Teams
Key figures
123
Publications since 2019
4
ERC since 2019
3
Spin-off since 2019
Key publications
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Multi-modal quantification of pathway activity with MAYANature Communications
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Kronos scRT: a uniform framework for single-cell replication timing analysisNature Communications
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Molecular basis of the dual role of the Mlh1-Mlh3 endonuclease in MMR and in meiotic crossover formationProceedings of the National Academy of Sciences
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Interactive analysis of single-cell epigenomic landscapes with ChromSCapeNature Communications
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News
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Drs. Allison Bardin and Valérie Borde elected members of the European EMBO organizationTo mark its 60th anniversary, the European Molecular Biology Organization (EMBO) has unveiled its 100 new members. Among them are nine French researchers, including Drs. Allison Bardin and Valérie Borde, team leaders at Institut Curie Research Center. Their mission: to promote the life sciences, guide strategic research choices and encourage the emergence of a new generation of excellent researchers.09/07/2024 -
Dr. Pierre Bost heads a new team combining single-cell exploration of viruses and tissue analysis in spaceAt the start of 2024, Dr. Pierre Bost arrived at Institut Curie in Paris as the new Junior Principal Investigator in the Dynamics of genetic information: fundamental bases and cancer unit (CNRS UMR3244 / Sorbonne Université) headed by Dr. Antonin Morillon.06/05/2024 -
World Triple Negative Breast Cancer Day: innovation to cure more womenWorld Triple Negative Breast Cancer Day, held on March 3rd, is a reminder that triple-negative breast cancers remain the most difficult to treat, and that only innovation and dynamic research can bring hope of curing more patients.01/03/2024 -
L’Institut Curie engagé sur le front des cancers masculinsEn novembre, mois de sensibilisation aux cancers masculins, l’Institut Curie met en lumière les spécificités de ces cancers. Ses trois sites, Paris, Saint-Cloud et Orsay, offrent à chaque patient une prise en charge optimale des cancers de la prostate, des testicules et du pénis, ainsi qu’un accès à l’innovation. Côté recherche, les équipes s’intéressent aux aspects biologiques et physiologiques de ces maladies.03/11/2023 -
Institut Curie’s latest progress at the AACR Annual Meeting 2023From April 14 to 19, 2023, in Orlando, USA, the international scientific and medical community comes together for the annual meeting of the American Association for Cancer Research, an opportunity for scientists from Institut Curie to present their findings in various fields of cancer research.17/04/2023 -
Institut Curie certified as Integrated cancer research site for the third timeFollowing a call for applications launched in April 2022, Institut Curie had its integrated cancer research site project certified by France’s Institut national du cancer (Inca). Its goal is to better understand tumor recurrences in order to better prevent, detect and treat them.20/02/2023
Scientific events
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4 Nov
2024
Seminar
11h-12h
Nucleosome Assembly, Epigenetic Inheritance, and Beyond
Parental histone recycling and transfer are essential for restoring histone-carried epigenetic information. During DNA replication, parental nucleosomes bearing epigenetic marks are disrupted ahead of each replication fork to allow duplex DNA unwinding and subsequent DNA synthesis. To maintain the fidelity of the epigenetic landscape, parental histones are recycled and transferred to the newly syn
18 Oct
2024
Seminar
11h-12h
Single-Cell and Spatial Transcriptomics and Epigenomics of Oligodendroglia in Development and in Multiple Sclerosis
Oligodendroglia (OLG) mediate myelination of neurons, a process that allows efficient electrical impulse transmission in the central nervous system. An autoimmune response in multiple sclerosis (MS) leads to OLG cell death, loss of myelin and neuropathology. Using single cell transcriptomics, we have previously identified disease-specific OLG populations in the&
2 Sep
2024
Seminar
11h-13h
Oxymatrine protects against severe acute pancreatitis by inhibiting the excessive formation of NETs via the LFA-1/PKC/ROS pathway in neutrophils
Severe acute pancreatitis (SAP) is a complex disease with rapid progress, many complications and high mortality, and there is no specific and effective treatment at present. Oxymatrine (OMT), as an active ingredient monomer of traditional Chinese medicine, has many pharmacological effects, including anti-inflammatory, anti-pathogen, and immunity regulating effects, but its therapeutic mechanism fo
21 Jun
2024
Seminar
11h-12h
Aberrant epi-transcriptomic alterations contribute to disease progression in breast cancer brain metastasis
1.7 million women globally will face a diagnosis of breast cancer, almost 40% of whom will develop metastatic disease. Breast cancer brain metastasis are a frequent and aggressive form of metastatic spread, with treatment options limited for each of the clinically relevant molecular subtypes. Advanced breast cancer cells display exceptional plasticity, capable of adapting to sequential bouts of th
5 Jun
2024
Seminar
15h-17h
Innovative Computational Tools for Single-Cell Lineage Tracing : CellBarcode and scMitoMut
Lineage-tracing is crucial for understanding development, tumors, and stem cell biology. This seminar will introduce two computational tools designed to enhance single-cell lineage tracing: CellBarcode and scMitoMut. These tools address the challenges of identifying DNA sequences and mtDNA variations in single-cell lineage tracing studies.
CellBarcode is an R package that helps researchers extr
CellBarcode is an R package that helps researchers extr
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