Unit
Dynamics of Genetic Information: fundamental bases and cancer (DIG-Cancer) (UMR3244)
Thematic areas of research:
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Unit
ANTONIN MORILLON / VALERIE BORDE
Dynamics of Genetic Information: fundamental bases and cancer (DIG-Cancer) (UMR3244)
The teams in this unit aim to better understand the mechanisms that maintain genome and epigenome integrity and expression and study how disruptions in these processes contribute to cancers and age-related human diseases.
Teams
Key figures
123
Publications since 2019
4
ERC since 2019
3
Spin-off since 2019
Key publications
All publications
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Multi-modal quantification of pathway activity with MAYANature Communications
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Kronos scRT: a uniform framework for single-cell replication timing analysisNature Communications
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Molecular basis of the dual role of the Mlh1-Mlh3 endonuclease in MMR and in meiotic crossover formationProceedings of the National Academy of Sciences
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Interactive analysis of single-cell epigenomic landscapes with ChromSCapeNature Communications
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News
All news
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Drs. Allison Bardin and Valérie Borde elected members of the European EMBO organizationTo mark its 60th anniversary, the European Molecular Biology Organization (EMBO) has unveiled its 100 new members. Among them are nine French researchers, including Drs. Allison Bardin and Valérie Borde, team leaders at Institut Curie Research Center. Their mission: to promote the life sciences, guide strategic research choices and encourage the emergence of a new generation of excellent researchers.09/07/2024 -
Dr. Pierre Bost heads a new team combining single-cell exploration of viruses and tissue analysis in spaceAt the start of 2024, Dr. Pierre Bost arrived at Institut Curie in Paris as the new Junior Principal Investigator in the Dynamics of genetic information: fundamental bases and cancer unit (CNRS UMR3244 / Sorbonne Université) headed by Dr. Antonin Morillon.06/05/2024 -
World Triple Negative Breast Cancer Day: innovation to cure more womenWorld Triple Negative Breast Cancer Day, held on March 3rd, is a reminder that triple-negative breast cancers remain the most difficult to treat, and that only innovation and dynamic research can bring hope of curing more patients.01/03/2024 -
L’Institut Curie engagé sur le front des cancers masculinsEn novembre, mois de sensibilisation aux cancers masculins, l’Institut Curie met en lumière les spécificités de ces cancers. Ses trois sites, Paris, Saint-Cloud et Orsay, offrent à chaque patient une prise en charge optimale des cancers de la prostate, des testicules et du pénis, ainsi qu’un accès à l’innovation. Côté recherche, les équipes s’intéressent aux aspects biologiques et physiologiques de ces maladies.03/11/2023 -
Institut Curie’s latest progress at the AACR Annual Meeting 2023From April 14 to 19, 2023, in Orlando, USA, the international scientific and medical community comes together for the annual meeting of the American Association for Cancer Research, an opportunity for scientists from Institut Curie to present their findings in various fields of cancer research.17/04/2023 -
Institut Curie certified as Integrated cancer research site for the third timeFollowing a call for applications launched in April 2022, Institut Curie had its integrated cancer research site project certified by France’s Institut national du cancer (Inca). Its goal is to better understand tumor recurrences in order to better prevent, detect and treat them.20/02/2023
Scientific events
All scientific events
21 Jun
2024
Seminar
11h-12h
Aberrant epi-transcriptomic alterations contribute to disease progression in breast cancer brain metastasis
1.7 million women globally will face a diagnosis of breast cancer, almost 40% of whom will develop metastatic disease. Breast cancer brain metastasis are a frequent and aggressive form of metastatic spread, with treatment options limited for each of the clinically relevant molecular subtypes. Advanced breast cancer cells display exceptional plasticity, capable of adapting to sequential bouts of th
5 Jun
2024
Seminar
15h-17h
Innovative Computational Tools for Single-Cell Lineage Tracing : CellBarcode and scMitoMut
Lineage-tracing is crucial for understanding development, tumors, and stem cell biology. This seminar will introduce two computational tools designed to enhance single-cell lineage tracing: CellBarcode and scMitoMut. These tools address the challenges of identifying DNA sequences and mtDNA variations in single-cell lineage tracing studies.
CellBarcode is an R package that helps researchers extr
CellBarcode is an R package that helps researchers extr
31 May
2024
Seminar
11h-12h
Cutting and Pasting DNA to Create our Adaptive Immune System
V(D)J recombination is essential for generating the adaptive immune response and unlimited number of different antibodies and antigen receptors. Encoded by multiple V, D and J gene segments, antigen receptors are assembled by programmed double-stranded DNA cleavage and imprecise re-joining. RAG1/2 recombinase initiates the process by stochastically cleaving DNA at a pair of recombination signal se
30 Apr
2024
Seminar
14h-15h
Demystifying Machine and Deep Learning and overview of their applications in biology
Artificial Intelligence is a broad term that is often misunderstood. Its subfields, such as machine and deep learning have achieved astonishing performances, such as some Large Language Models passing the Turing Test or AlphaFold offering a solution to a 50 years old problem. Because new technologies in medecine and biology generate massive amounts of high quality data (omics, images, clinicals, m
5 Apr
2024
Institutional seminar "Mayent - Rothschild"
11h-12h
A garden of forking paths: branching, switching and reversal in meiotic recombination
Abstract
Meiotic recombination involves repair of double strand DNA breaks by homologous recombination to form crossovers and noncrossovers. Current models suggest that different mechanisms form these two products: noncrossovers by synthesis dependent strand annealing; COs by double Holliday junction formation and resolution. In testing these predictions, we found evidence for remarkable dynami
Meiotic recombination involves repair of double strand DNA breaks by homologous recombination to form crossovers and noncrossovers. Current models suggest that different mechanisms form these two products: noncrossovers by synthesis dependent strand annealing; COs by double Holliday junction formation and resolution. In testing these predictions, we found evidence for remarkable dynami