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Unit
ANTONIN MORILLON / VALERIE BORDE
Dynamics of Genetic Information: fundamental bases and cancer (DIG-Cancer) (UMR3244)

The teams in this unit aim to better understand the mechanisms that maintain genome and epigenome integrity and expression and study how disruptions in these processes contribute to cancers and age-related human diseases.

 

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123
Publications since 2019
4
ERC since 2019
3
Spin-off since 2019
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23 Nov
2022
Seminar
09h-23h
Overcoming experimental and computational limitations of multiplexed imaging to study viral infections
Recent technological advances in imaging now allow to simultaneously measure dozens to

hundreds of proteins, either using successive rounds of standard IF imaging or using heavy-metal conjugated antibodies. This has enabled deep spatial characterization of various healthy and diseased tissues, ranging from healthy human kidney to human breast cancer, thus providing a wealth of knowledge. Howeve
1 Apr
2022
Seminar
11h-23h
Functions of biomolecular condensates assembled in response to DNA damage
DNA repair mechanisms are crucial for organismal health and survival. All living organisms have evolved a multitude of mechanisms to repair alterations in the primary structure of DNA. DNA damage response (DDR) proteins often accumulate in nuclear foci seemingly similar to biomolecular condensates, but the intrinsic molecular organization and the functions that arise specifically from the assembly
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