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Lung cancer
COCOON
A Phase 2, open-label, randomized trial evaluating the impact of enhanced versus standard;dermatologic management on selected dermatologic adverse events among patients with locally;advanced or metastatic EGFR-mutated NSCLC treated first-line with;amivantamab + lazertinib.
- Open at Paris since : 24/04/2024
- Target : Adult
- Phase : Phase II
Trial description
The primary objective is to evaluate whether enhanced dermatologic management can reduce the incidence;of Grade =2 DAEIs by Week 12 when compared with standard-of-care skin management in participants;with locally advanced or metastatic Stage IIIB/C-IV EGFR-mutated NSCLC treated first-line with;amivantamab and lazertinib. The key secondary objectives are to further characterize dermatologic toxicity;and the impact on participantsÀ quality oflife.
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