Research Director Inserm
Recherche - Paris
Spécialités / domaines
Integrative tumor biology, immunology and environment,
Basic research,
Translational research,
Functions within Institut Curie:

Fatima Mechta-Grigoriou, PhD in Science specialized in Cancer Biology. She is Research Director of Exceptional Class at Inserm and Director of the “Stress and Cancer” laboratory at Institut Curie. She is also the deputy director of the research unit U830,  Cancer, Heterogeneity, Instability and Plasticity at Curie Institute and has recently been nominated the Scientific Director of the Cancéropôle Ile de France.

She is an internationally recognized expert investigating the impact of tumor heterogeneity in immunosuppression, metastatic spread and resistance to treatment. Her lab has identified different fibroblast (CAF) populations in several cancers, such as breast, ovarian and lung cancer and revealed that some specific CAF are involved in immunosuppression and resistance to immunotherapies. Her lab also demonstrated the paradoxical effects of Reactive Oxygen Species. Although they are involved in tumor growth and spread, they can also improve sensitivity to chemotherapy.

She received several awards, such as the Rosen Prize 2021, the Grand Prize of the Foundation Del Duca 2018 and the Grand Prize of the Pink Ribbon 2017.

A catalog of numerical centrosome defects in epithelial ovarian cancers
EMBO Molecular Medicine
Jean‐Philippe Morretton, Anthony Simon, Aurélie Herbette, Jorge Barbazan, Carlos Pérez‐González, Camille Cosson, Bassirou Mboup, Aurélien Latouche, Tatiana Popova, Yann Kieffer, Anne‐Sophie Macé, Pierre Gestraud, Guillaume Bataillon, Véronique Becette, Didier Meseure, André Nicolas, Odette Mariani, Anne Vincent‐Salomon, Marc‐Henri Stern, Fatima Mechta‐Grigoriou, Sergio Roman Roman, Danijela Matic Vignjevic, Roman Rouzier, Xavier Sastre‐Garau, Oumou Goundiam, Renata Basto
Single-cell transcriptomics reveals shared immunosuppressive landscapes of mouse and human neuroblastoma
Journal for ImmunoTherapy of Cancer
Ana Costa, Cécile Thirant, Amira Kramdi, Cécile Pierre-Eugène, Caroline Louis-Brennetot, Orphée Blanchard, Didier Surdez, Nadege Gruel, Eve Lapouble, Gaëlle Pierron, Deborah Sitbon, Hervé Brisse, Arnaud Gauthier, Paul Fréneaux, Mylène Bohec, Virginie Raynal, Sylvain Baulande, Renaud Leclere, Gabriel Champenois, Andre Nicolas, Didier Meseure, Angela Bellini, Aurelien Marabelle, Birgit Geoerger, Fatima Mechta-Grigoriou, Gudrun Schleiermacher, Laurie Menger, Olivier Delattre, Isabelle Janoueix-Lerosey