FATIMA MECHTA-GRIGORIOU

Doctor,
Research Director Inserm
Recherche - Paris
Spécialités / domaines
Bioinformatics,
Biology,
Integrative tumor biology, immunology and environment,
Cancer,
Gynécologie,
Heterogeneity,
Immunothérapie,
Metabolomics,
Basic research,
Translational research,
Sénologie
Functions within Institut Curie:
Présentation

Fatima Mechta-Grigoriou, PhD in Science specialized in Cancer Biology. She is Research Director of Exceptional Class at Inserm and Director of the “Stress and Cancer” laboratory at Institut Curie. She is also the deputy director of the research unit U830,  Cancer, Heterogeneity, Instability and Plasticity at Curie Institute and has recently been nominated the Scientific Director of the Cancéropôle Ile de France.

She is an internationally recognized expert investigating the impact of tumor heterogeneity in immunosuppression, metastatic spread and resistance to treatment. Her lab has identified different fibroblast (CAF) populations in several cancers, such as breast, ovarian and lung cancer and revealed that some specific CAF are involved in immunosuppression and resistance to immunotherapies. Her lab also demonstrated the paradoxical effects of Reactive Oxygen Species. Although they are involved in tumor growth and spread, they can also improve sensitivity to chemotherapy.

She received several awards, such as the Rosen Prize 2021, the Grand Prize of the Foundation Del Duca 2018 and the Grand Prize of the Pink Ribbon 2017.

Publications
Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate
Cancer Research
Judith Goncalves, Sophie Moog, Aurélie Morin, Géraldine Gentric, Sebastian Müller, Alexander P. Morrell, Katarina Kluckova, Theodora J. Stewart, Cynthia L. Andoniadou, Charlotte Lussey-Lepoutre, Paule Bénit, Alpesh Thakker, Lisa Vettore, Jennie Roberts, Raphaël Rodriguez, Fatima Mechta-Grigoriou, Anne-Paule Gimenez-Roqueplo, Eric Letouzé, Daniel A. Tennant, Judith Favier