Active shape programming drives Drosophila wing disc eversion
Authors
Jana F. Fuhrmann, Abhijeet Krishna, Joris Paijmans, Charlie Duclut, Greta Cwikla, Suzanne Eaton, Marko Popović, Frank Jülicher, Carl D. Modes, Natalie A. Dye
Abstract
How complex 3D tissue shape emerges during animal development remains an important open question in biology and biophysics. Here, we discover a mechanism for 3D epithelial shape change based on active, in-plane cellular events that is analogous to inanimate “shape programmable” materials, which undergo blueprinted 3D shape transformations from in-plane gradients of spontaneous strains. We study eversion of the