Aneuploidy causes premature differentiation of neural and intestinal stem cells
Authors
Delphine Gogendeau, Katarzyna Siudeja, Davide Gambarotto, Carole Pennetier, Allison J. Bardin, Renata Basto
Abstract
Abstract
Aneuploidy is associated with a variety of diseases such as cancer and microcephaly. Although many studies have addressed the consequences of a non-euploid genome in cells, little is known about their overall consequences in tissue and organism development. Here we use two different mutant conditions to address the consequences of aneuploidy during tissue development and homeostasis in