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- Assessment of presumed small-molecule ligands of telomeric i-DNA by BioLayer Interferometry (BLI)
Assessment of presumed small-molecule ligands of telomeric i-DNA by BioLayer Interferometry (BLI)
Authors
Hugues Bonnet, Maeva Morel, Alexandre Devaux, Joseph Boissieras, Anton Granzhan, Benjamin Elias, Thomas Lavergne, Jérôme Dejeu, Eric Defrancq
Abstract
Biolayer interferometry and circular dichroism spectroscopy were used to investigate the interaction between previously reported i-motif DNA ligands and folded or unfolded i-DNA in acidic (pH 5.5) and near-neutral (pH 6.5) conditions.