- Home >
- Publications >
- Cigarette smoking induces human CCR6+Th17 lymphocytes senescence and VEGF-A secretion
Cigarette smoking induces human CCR6+Th17 lymphocytes senescence and VEGF-A secretion
Authors
Indoumady Baskara, Stéphane Kerbrat, Maylis Dagouassat, Hoang Quy Nguyen, Maude Guillot-Delost, Mathieu Surenaud, Claude Baillou, François M. Lemoine, Didier Morin, Jorge Boczkowski, Sabine Le Gouvello
Abstract
Abstract
Chronic exposure to environmental pollutants is often associated with systemic inflammation. As such, cigarette smoking contributes to inflammation and lung diseases by inducing senescence of pulmonary cells such as pneumocytes, fibroblasts, and endothelial cells. Yet, how smoking worsens evolution of chronic inflammatory disorders associated with Th17 lymphocytes, such as rheumatoid arthritis, psoriasis, Crohn’s disease, and multiple sclerosis, is largely unknown. Results from human studies show an increase in inflammatory CD4