A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals
Authors
Petar Scepanovic, , Flavia Hodel, Stanislas Mondot, Valentin Partula, Allyson Byrd, Christian Hammer, Cécile Alanio, Jacob Bergstedt, Etienne Patin, Mathilde Touvier, Olivier Lantz, Matthew L. Albert, Darragh Duffy, Lluis Quintana-Murci, Jacques Fellay
Abstract
Abstract
Background
The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the
Results
Among 110 demographic, clinical, and environmental factors, 11 were identified as significantly correlated with
Conclusion
In a well-characterized cohort of healthy individuals, we identified several non-genetic variables associated with fecal microbiome diversity. In contrast, host genetics only had a negligible influence. Demographic and environmental factors are thus the main contributors to fecal microbiome composition in healthy individuals.
Trial registration
ClinicalTrials.gov identifier