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- The different activities of RNA G-quadruplex structures are controlled by flanking sequences
The different activities of RNA G-quadruplex structures are controlled by flanking sequences
Authors
Alice J-L Zheng, Aikaterini Thermou, Pedro Guixens Gallardo, Laurence Malbert-Colas, Chrysoula Daskalogianni, Nathan Vaudiau, Petter Brohagen, Anton Granzhan, Marc Blondel, Marie-Paule Teulade-Fichou, Rodrigo Prado Martins, Robin Fahraeus
Abstract
The role of G-quadruplex (G4) RNA structures is multifaceted and controversial. Here, we have used as a model the EBV-encoded EBNA1 and the Kaposi’s sarcoma-associated herpesvirus (KSHV)-encoded LANA1 mRNAs. We have compared the G4s in these two messages in terms of nucleolin binding, nuclear mRNA retention, and mRNA translation inhibition and their effects on immune evasion. The G4s in the
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