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- The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks
The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks
Authors
Ana Teixeira-Silva, Anissia Ait Saada, Julien Hardy, Ismail Iraqui, Marina Charlotte Nocente, Karine Fréon, Sarah A. E. Lambert
Abstract
Abstract
Replication requires homologous recombination (HR) to stabilize and restart terminally arrested forks. HR-mediated fork processing requires single stranded DNA (ssDNA) gaps and not necessarily double strand breaks. We used genetic and molecular assays to investigate fork-resection and restart at dysfunctional, unbroken forks in