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Engineered niches support the development of human dendritic cells in humanized mice
Authors
Giorgio Anselmi, Kristine Vaivode, Charles-Antoine Dutertre, Pierre Bourdely, Yoann Missolo-Koussou, Evan Newell, Oliver Hickman, Kristie Wood, Alka Saxena, Julie Helft, Florent Ginhoux, Pierre Guermonprez
Abstract
Abstract
Classical dendritic cells (cDCs) are rare sentinel cells specialized in the regulation of adaptive immunity. Modeling cDC development is crucial to study cDCs and harness their therapeutic potential. Here we address whether cDCs could differentiate in response to trophic cues delivered by mesenchymal components of the hematopoietic niche. We find that mesenchymal stromal cells engineered to express membrane-bound FLT3L and stem cell factor (SCF) together with CXCL12 induce the specification of human cDCs from CD34