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Harnessing an emissive guanine surrogate to design small-molecule fluorescent chemosensors of <i>O</i><sup>6</sup>-methylguanine-DNA-methyltransferase (MGMT)

1 Jan 2022Organic &amp; Biomolecular Chemistry

DOI : 10.1039/d2ob00208f

Authors

Alexandra Fillion, Jaime Franco Pinto, Anton Granzhan

Abstract

Activity of O6-methylguanine-DNA-methyltransferase (MGMT) can be monitored in real time using chemosensors that generate an emissive guanine analogue thienoguanine (thGN).

Members

ANTON GRANZHAN

CNRS Researcher