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The immune system profoundly restricts intratumor genetic heterogeneity

30 Nov 2018Science Immunology

DOI : 10.1126/sciimmunol.aat1435

Authors

Idan Milo, Marie Bedora-Faure, Zacarias Garcia, Ronan Thibaut, Leïla Périé, Guy Shakhar, Ludovic Deriano, Philippe Bousso

Abstract

Host immune responses and checkpoint inhibition reduce clonal and genetic intratumor diversity.