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Islet-reactive CD8 + T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors

9 Feb 2018Science Immunology

DOI : 10.1126/sciimmunol.aao4013

Authors

Slobodan Culina, Ana Ines Lalanne, Georgia Afonso, Karen Cerosaletti, Sheena Pinto, Guido Sebastiani, Klaudia Kuranda, Laura Nigi, Anne Eugster, Thomas Østerbye, Alicia Maugein, James E. McLaren, Kristin Ladell, Etienne Larger, Jean-Paul Beressi, Anna Lissina, Victor Appay, Howard W. Davidson, Søren Buus, David A. Price, Matthias Kuhn, Ezio Bonifacio, Manuela Battaglia, Sophie Caillat-Zucman, Francesco Dotta, Raphael Scharfmann, Bruno Kyewski, Roberto Mallone, Jean-Claude Carel, Nadia Tubiana-Rufi, Laetitia Martinerie, Amélie Poidvin, Evelyne JacqzAigrain, Laurence Corvez, Véronique Berruer, Jean-François Gautier, Baz Baz, Nassima Haddadi, Fabrizio Andreelli, Chloé Amouyal, Sophie Jaqueminet, Olivier Bourron, Eric Dasque, Agnès Hartemann, Amal Lemoine-Yazigi, Danièle Dubois-Laforgue, Florence Travert, Marilyne Feron, Patrice Rolland, Valérie Vignali, Michel Marre, Philippe Chanson, Claire Briet, Pierre-Jean Guillausseau, Leila Ait-Bachir, Carole Collet, Frédéric Beziaud, Virginie Desforges-Bullet, Gwenaelle Petit-Aubert, Sophie Christin-Maitre, Bruno Fève, Camille Vatier, Nathalie Bourcigaux, Céline Lautridou, Najiba Lahlou, Prissile Bakouboula, Caroline Elie, Hélène Morel, Jean-Marc Treluyer, Marie-Claude Gagnerault, Claire Maillard, Anna Jones,

Abstract

Islet-reactive CD8 + T cells are common in the periphery, but home to the pancreas preferentially in the context of type 1 diabetes.