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- Methyl-branched lipids promote the membrane adsorption of α-synuclein by enhancing shallow lipid-packing defects
Methyl-branched lipids promote the membrane adsorption of α-synuclein by enhancing shallow lipid-packing defects
Authors
Matthias Garten, Coline Prévost, Clotilde Cadart, Romain Gautier, Luc Bousset, Ronald Melki, Patricia Bassereau, Stefano Vanni
Abstract
Reconstitution experiments on Giant Unilamellar Vesicles and Molecular Dynamics Simulations indicate that alpha-synuclein binds to neutral flat membranes in the presence of methyl-branched lipids.
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