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- The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric heterochromatin
The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric heterochromatin
Authors
Christèle Maison, Delphine Bailly, Jean-Pierre Quivy, Geneviève Almouzni
Abstract
Abstract
The trimethylation of histone H3 on lysine 9 (H3K9me3) – a mark recognized by HP1 that depends on the Suv39h lysine methyltransferases (KMTs) – has provided a basis for the reader/writer model to explain HP1 accumulation at pericentric heterochromatin in mammals. Here, we identify the Suv39h1 paralog, as a unique enhancer of HP1α sumoylation both
Members

GENEVIEVE ALMOUZNI
Directeur de recherche CNRS
CHRISTELE MAISON
Chargé de recherche CNRS
JEAN-PIERRE QUIVY
Directeur de recherche CNRS