Cross-talk between cell mechanics, cell shape and cell fate

A precise control of cell morphology is key for cell physiology, and cell shape deregulation is at the heart of many pathological disorders. Furthermore, transitions in cellular fate and state are often associated with changes in cell shape, and strong evidence points to the existence of feedbacks between mechanics, morphology and fate decisions. Cell morphology is intrinsically controlled by mechanical forces acting on the cell surface, to understand shape it is thus essential to investigate the regulation of cellular mechanics. I will discuss how cellular mechanical properties are regulated, how they drive cellular shape changes, and the cross-talk between mechanics and state in cellular transitions.

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Part of this mini-series of joint seminars between BDD and PCC, don’t miss the talk given by Kevin Chalut on  “The ECM in tissue repair and development​” on 28/05 11:30am at Amphithéâtre Marie Curie.