Mechanics and stress in cellular development, adaptation and aging

Mechanical processes are central to diverse cellular functions but can also be sources of cellular stress leading to aging phenotypes. My lab currently investigates three problems related to cell mechanics and stress: 1) how intracellular fluid dynamics coupled with cytoskeletal forces drive early mammalian development and reproductive aging; 2) how stress-induced protein aggregation and subsequent disaggregation are orchestrated by and affect organelles such as mitochondria and ER; and 3) the interplay between biophysical stress and chromosome instability and its contribution to cellular adaptation and cancer evolution. I will present a combination of recent findings in two of these areas of our research.