Adjusting the timing of mammalian development.

Pluripotency provides the foundation of embryonic development and regenerative medicine. Pluripotency is also remarkably dynamic, as it can alternate between different states and can be promptly resolved to allow lineage specification. As such, embryonic development relies on stem cell function in balance with differentiation. We investigate how this balance is maintained in coordination with the environment and the protective measures the embryos take at times of scarcity. Our mission is to decode the process of dormancy and identify the genetic, epigenetic, and metabolic mechanisms that govern this fascinating phenomenon.