Postdoctoral Position in Epigenetics and Pediatric Oncology (F/M)

At the Paris campus of the Institute Curie, the Translational Research in Pediatric Oncology (RTOP; Head: Dr. G. Schleiermacher) team of INSERM Unit 1330 (CONCERT; Director: Olivier Ayrault) develops methods for analyzing molecules isolated from peripheral samples (circulating cell-free DNA, cell-free RNAs, proteins) in large cohorts of patients with high-risk pediatric cancers (neuroblastoma, other high-risk cancers) in order to study mechanisms of oncogenesis and treatment resistance.

We are currently recruiting a postdoctoral researcher whose mission will be to develop approaches for studying methylation in patients with neuroblastoma, to contribute to improving the diagnosis and management of these patients, as well as our understanding of tumor development and metastatic dissemination. The candidate will work in an interdisciplinary environment involving next-generation sequencing methods, molecular tool development, and cell biology/screening applications, using both commercial and in-house solutions.

Essential duties and responsibilities

·        Analysis of methylome dysregulation at the tumor level and in circulating DNA in neuroblastoma, to identify tumor subgroups and to analyze the role of divergent profiles in treatment resistance.

·        Promoting the study of genetic and epigenetic alterations, and DNA-protein interactions, based on the development of new approaches to liquid biopsy analysis (NGS, WES, ChipSeq, exosomes, and other techniques) in neuroblastoma.

·        Interface with the team's bioinformaticians for data analysis and interpretation.