Research Engineer Process Development (F/M)
- Research Center
The Curie Institute Research Center
The “Institut Curie” is a major player in the research and fight against cancer. It consists of a hospital and a Research Center of more than 1000 employees with a strong international representativeness.
The objective of the Curie Institute Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.
Laboratory - CellAction
CellAction is part of Institut Curie’s commitment to building unique expertise in cell and gene therapy. It integrates multidisciplinary competencies in bioinformatics, target discovery and validation, molecular biology, genome editing, viral and non-viral vector design, cell engineering, and the development of in vitro and in vivo tumor models for cell and gene therapy applications. Furthermore, CellAction provides pre-GMP process development expertise, aiming to generate fully characterized, GMP-ready cell therapy products that can be manufactured in dedicated GMP facilities and subsequently evaluated in clinical settings.
In 2025, CellAction was permanently established at the Saint-Cloud site of Institut Curie.
At the Process Development group at CellAction, our activities focus on the development and optimization of manufacturing processes for cell- and gene-based therapies, ensuring translational feasibility and compliance with regulatory standards for clinical-grade production.
https://curie.fr/cellaction-un-laboratoire-unique-pour-lacces-aux-therapies-cellulaires-et-geniques
Missions / Responsibilities
· Develop and optimize manufacturing processes for cell and gene therapies, including viral/non-viral vectors and genome editing.
· Transfer pre-GMP processes into robust, reproducible workflows suitable for clinical manufacturing.
· Develop analytical methods and monitor critical process parameters (CPPs) and critical quality attributes (CQAs) to ensure product quality.
· Collaborate with multidisciplinary teams, contribute to troubleshooting, and support continuous process improvement.
· Prepare technical documentation and ensure compliance with GMP and regulatory requirements.
· Identify innovative approaches to improve process efficiency and maintain technology watch in the field of cell and gene therapy.
What We Offer
- Opportunity to work on cutting-edge therapies
- Dynamic and collaborative environment
- Competitive salary and benefits package
- Career development opportunities
- Master's degree or PhD in Biotechnology, Biochemical Engineering, or related field
- 2–5 years of experience in process development (cell therapy, gene therapy, or drug development)
Preferred Qualifications
- Demonstrated proficiency in aseptic mammalian cell culture, with preference for experience in primary T-cell culture, cell activation, and cell expansion systems (flasks, bags, or bioreactors), viral transduction techniques, immunophenotyping (e.g. Flow cytometry)
- Knowledge of analytical characterization and critical quality attributes (CQAs), preferably for cell and gene therapy drug products, including titer, purity, potency, and sterility.
- Hands-on experience with site-specific gene-editing technologies (e.g., CRISPR-Cas) is desirable; however, it is not mandatory.
- Excellent written and verbal communication skills, with the ability to clearly present technical and scientific information to multidisciplinary teams.
- Knowledge of GMP environment and regulatory expectations
- Strong analytical and problem-solving skills
- Ability to work in a multidisciplinary and fast-paced environment
- Fluent in English; French is a plus
Required Skills and Competencies
- Ability to work independently in managing routine tasks
- Good communication skills
- Strong organizational skills
- Adaptability and responsiveness
- Ability to work effectively as part of a team
All our opportunities are open to individuals with disabilities.
Contract Information
Contract type: Fixed-term contract (CDD)
Start date: As soon as possible
Contract duration: 12 months, renewable for an additional 12 months
Working time: Full-time – 39 hours per week
Salary: According to current salary scales
Benefits: Company cafeteria, 70% coverage of annual public transportation pass, company health insurance
Location: Saint-Cloud
Contact
Please send your CV and cover letter
Publication date: 25/09/2026
Deadline for application: once filled
Faithful to the legacy of its founder, the Institut Curie is deeply committed to promoting equal opportunities, diversity, and inclusion. Convinced that diversity of backgrounds and experiences contributes to collective performance, we strive to provide everyone with a respectful and equitable working environment and encourage all candidates to apply for our job opportunities.
https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf