FABRICE LECLERC

As a CNRS Senior Scientist at the Institute Curie, my research program focuses on employing computational and modeling techniques to investigate the intricate structure-function and struture-activity/selectivity relationships of RNA molecules across diverse levels of complexity, encompassing 2D, and 3D representations. My research efforts are organized around the following key areas: RNA Modeling, RNA structure predictions and RNA biophysics, leveraging computational docking methods and fragment-based design approaches to model and predict RNA-protein interactions and to develop novel oligonucleotide therapeutics. This research integrates principles from bioinformatics, theoretical and computational chemistry, and computational biology to advance our understanding of RNA biology and to contribute to the development of new therapeutic strategies.