Unit

Chemistry and Modelling for Biology of Cancer (UMR9187 / U1196)

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UMR9187/U1196 - retraite - 2023-04-18

Retraite scientifique de l'UMR9187/U1196 au Domaine Saint-Paul à Saint-Rémy-lès-Chevreuse le 18 avril 2023

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Unit
FLORENCE MAHUTEAU-BETZER
Chemistry and Modelling for Biology of Cancer (UMR9187 / U1196)

The central activity of the CMBC unit is to develop small molecules to probe and control the biological activities of key targets involved in cancer. These are non B-nucleic acid structures (G-quadruplexes, Abasic sites, …) and proteins (TAM kinases, non B-nucleic acid structures interacting proteins, …).

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10
filed patents over the last 5 years
1
drug in clinical phase for ulcerative colitis (Phase 3 will start at the end of 2021)
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26 Jun
2023
Seminar
12h-12h
Chemical Biology Tools to unravel biological functions of nucleic acids secondary structures
DNA and RNA containing runs of 3 or 4 adjacent guanines may spontaneously arrange into four-stranded DNA supramolecular structures called G-quadruplexes (G4). These non-canonical structures are likely to form in G-rich regions throughout the genome and thus are assumed to have functional roles in key biological processes, such as replication, transcription, repair, and recombination, and thereby t
26 Jun
2023
Seminar
11h-12h
Proximity-induced targeted RNA degradation for mapping RNA modifications and drugging SARS-CoV-2 genome
Using small molecules to modulate RNA stability is an emerging paradigm which holds promise to greatly expand the space of druggable biomolecules. In this talk I will present two divergent applications of small molecule-induced targeted RNA degradation. Firstly, we devised a click chemistry- and degradation-based method to map RNA modifications, meCLICK-Seq. This unorthodox approach enabled discov
26 Jun
2023
Seminar
11h-11h
Molecular Engineering of Light-Activated Probes for Precision Diagnostics, Therapy, and Opto-Biology
Probing living systems with light-responsive molecules has unlocked new perspectives on the study of biological targets, but also on clinical diagnostics and targeted therapies. However, further progress in opto-biology requires a level of precision that standard, non-specific photo-activation cannot provide. The challenge therefore lies in the development of a toolbox of light-activated probes ab
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