Directory of Doctors and Researchers

HELENE SALMON

Doctor
Recherche - Paris
Spécialités / domaines
Research Center
Functions within Institut Curie:
Présentation

Hélène Salmon's research focuses on immune cell dynamics in solid tumors and on cancer immunotherapy strategies modulating the tumor microenvironment. Her prior work shed light on the importance of the stromal extracellular matrix in the control of T cell migration in human solid tumors, and showed that the paucity of activated CD103+ dendritic cells in tumors limits checkpoint blockade efficacy. The main goals of her team's reasearch are to define the contribution of stromal cells to tumor immunity and to develop new strategies to target the stromal compartment and improve tumor response to current immunotherapies.

Publications
A druggable copper-signalling pathway that drives inflammation
Nature
Stéphanie Solier, Sebastian Müller, Tatiana Cañeque, Antoine Versini, Arnaud Mansart, Fabien Sindikubwabo, Leeroy Baron, Laila Emam, Pierre Gestraud, G. Dan Pantoș, Vincent Gandon, Christine Gaillet, Ting-Di Wu, Florent Dingli, Damarys Loew, Sylvain Baulande, Sylvère Durand, Valentin Sencio, Cyril Robil, François Trottein, David Péricat, Emmanuelle Näser, Céline Cougoule, Etienne Meunier, Anne-Laure Bègue, Hélène Salmon, Nicolas Manel, Alain Puisieux, Sarah Watson, Mark A. Dawson, Nicolas Servant, Guido Kroemer, Djillali Annane, Raphaël Rodriguez
Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors
Cancer Discovery
John A. Grout, Philemon Sirven, Andrew M. Leader, Shrisha Maskey, Eglantine Hector, Isabelle Puisieux, Fiona Steffan, Evan Cheng, Navpreet Tung, Mathieu Maurin, Romain Vaineau, Lea Karpf, Martin Plaud, Anne-Laure Begue, Koushik Ganesh, Jérémy Mesple, Maria Casanova-Acebes, Alexandra Tabachnikova, Shilpa Keerthivasan, Alona Lansky, Jessica Le Berichel, Laura Walker, Adeeb H. Rahman, Sacha Gnjatic, Nicolas Girard, Marine Lefevre, Diane Damotte, Julien Adam, Jerome C. Martin, Andrea Wolf, Raja M. Flores, Mary Beth Beasley, Rachana Pradhan, Soren Muller, Thomas U. Marron, Shannon J. Turley, Miriam Merad, Ephraim Kenigsberg, Hélène Salmon
Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammation
bioRxiv
Stéphanie Solier, Sebastian Müller, Tatiana Cañeque, Antoine Versini, Leeroy Baron, Pierre Gestraud, Nicolas Servant, Laila Emam, Arnaud Mansart, G. Dan Pantoș, Vincent Gandon, Valentin Sencio, Cyril Robil, François Trottein, Anne-Laure Bègue, Hélène Salmon, Sylvère Durand, Ting-Di Wu, Nicolas Manel, Alain Puisieux, Mark A. Dawson, Sarah Watson, Guido Kroemer, Djillali Annane, Raphaël Rodriguez
Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification
Cancer Cell
Andrew M. Leader, John A. Grout, Barbara B. Maier, Barzin Y. Nabet, Matthew D. Park, Alexandra Tabachnikova, Christie Chang, Laura Walker, Alona Lansky, Jessica Le Berichel, Leanna Troncoso, Nausicaa Malissen, Melanie Davila, Jerome C. Martin, Giuliana Magri, Kevin Tuballes, Zhen Zhao, Francesca Petralia, Robert Samstein, Natalie Roy D’Amore, Gavin Thurston, Alice O. Kamphorst, Andrea Wolf, Raja Flores, Pei Wang, Sören Müller, Ira Mellman, Mary Beth Beasley, Hélène Salmon, Adeeb H. Rahman, Thomas U. Marron, Ephraim Kenigsberg, Miriam Merad
EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer
Nature Communications
Li Wang, Abdel Saci, Peter M. Szabo, Scott D. Chasalow, Mireia Castillo-Martin, Josep Domingo-Domenech, Arlene Siefker-Radtke, Padmanee Sharma, John P. Sfakianos, Yixuan Gong, Ana Dominguez-Andres, William K. Oh, David Mulholland, Alex Azrilevich, Liangyuan Hu, Carlos Cordon-Cardo, Hélène Salmon, Nina Bhardwaj, Jun Zhu, Matthew D. Galsky
Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition
Immunity
Hélène Salmon, Juliana Idoyaga, Adeeb Rahman, Marylène Leboeuf, Romain Remark, Stefan Jordan, Maria Casanova-Acebes, Makhzuna Khudoynazarova, Judith Agudo, Navpreet Tung, Svetoslav Chakarov, Christina Rivera, Brandon Hogstad, Marcus Bosenberg, Daigo Hashimoto, Sacha Gnjatic, Nina Bhardwaj, Anna Karolina Palucka, Brian D. Brown, Joshua Brody, Florent Ginhoux, Miriam Merad
Actualites
Directory of Doctors and Researchers