Unit
Immunity and Cancer (U932)
Thematic areas of research:
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Unit
ANA-MARIA LENNON / OLIVIER LANTZ
Immunity and Cancer (U932)
Created in 2005, the INSERM U932 Unit is composed of 10 teams, spread over two buildings (Hôpital Curie and Constant-Burg building, rue Lhomond), with a total of about 120 people.
Teams
Key figures
334
publication since 2017
6
ERC since 2008
3
start-ups
Key publications
All publications
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Constitutive Siglec-1 expression confers susceptibility to HIV-1 infection of human dendritic cell precursorsProceedings of the National Academy of Sciences
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Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activationJournal of Experimental Medicine
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News
All news
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Un nouveau projet d’envergure pour comprendre et combattre le mélanome uvéalL’Institut Curie a lancé en septembre dernier un projet ambitieux dans la lutte contre le mélanome uvéal, le cancer de l’œil le plus fréquent chez l’adulte. En collaboration avec le Melanoma Patients Network Europe (MPNE) et soutenu par le Secrétaire adjoint américain à la défense pour les affaires sanitaires et approuvé par le ministère américain de la Défense, le projet a pour objectifs d’identifier la prédisposition génétique, la tumorigenèse ainsi que les réponses immunitaires spécifiques à ce cancer.31/10/2023
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The key role of “junk” DNA in the exhaustion of T cells in cancerIt was believed for a long time that half of the genome served no purpose. So such an extent that we talked about “junk” DNA when referring to these “transposable elements” 1that repeat in the host genome in a dispersed manner. Researchers at Institut Curie, CNRS and Inserm have just shown that the expression of these elements changes completely during the course of the phenomenon known as “exhaustion” of certain cells of the immune system (T cells) that occur in cancers. This discovery, published in the journal Science Immunology on October 27, 2023, offers new prospects for immunotherapy.22/11/2023
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Contrecarrer les effets du vieillissement et l’apparition des cancers : de nouveaux résultats prometteursCancer et vieillissement sont des processus intimement liés et pourtant, les mécanismes au cœur de cette relation demeurent assez méconnus. En étudiant les cellules immunitaires dans le poumon, des chercheurs de l’Institut Curie et de l’Inserm ont apporté de nouvelles connaissances sur le sujet. Ils révèlent notamment que cibler les ruptures de l’enveloppe nucléaire de ces cellules représenterait une nouvelle opportunité d’intervention thérapeutique dans les maladies liées à l’âge, notamment le cancer, améliorant ainsi la qualité de vie des personnes âgées sur le long terme. Financés par la Fondation ARC, ces travaux viennent d’être publiés dans la revue Nature Aging.22/09/2023
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Immunotherapy, a new ally against cervical cancer?Could chemoradiotherapy in combination with immunotherapy help fight cervical cancer? To start to answer the question, a team from Institut Curie conducted a phase-I clinical trial. The results, published in Nature Communications, do not simply reveal good tolerance for the treatment, but they also highlight the biomarkers predictive of its efficacy.07/09/2023
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Manger des brocolis pour limiter les allergies cutanéesLa sévérité des allergies cutanées peut varier en fonction de nombreux facteurs environnementaux, et notamment du régime alimentaire. Cependant, jusqu’à présent, la contribution de nutriments spécifiques n’avait pas été bien documentée. Dans une nouvelle étude, des chercheurs et chercheuses de l’Inserm et de l’Institut Curie ont montré que l’absence dans l’alimentation de composés que l’on retrouve dans certains légumes, en particulier les brocolis et les choux, pouvait aggraver les allergies cutanées dans des modèles animaux.17/05/2023
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Institut Curie - Institut Pasteur partnership: two joint projects to promote innovation and advancement of knowledgeImplementing their collaborative research strategy, Institut Curie and Institut Pasteur have raised the impressive amount of €600,000 to finance two research projects involving two teams from each organization. The MUCTOLIN project, looking at the role of tolerance induced by mucus during Listeria infection, and the TicTac project, which aims to study the effects of geometry on the healthy or cancerous status of a cell or on its development, were chosen.28/04/2023
Scientific events
All scientific events
30 Jun
2023
Institutional seminar "Mayent - Rothschild"
14h-23h
Type I IFNs in health and disease: from trisomy 21 to cancer
Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. We will discuss our results by addressing the biology of IFN in Down syndrome (DS). This syndrome is the consequence of a chromosomal anomaly known as "trisomy 21" in which chromosome 21 is partially or totally tripled. The subunits that make up
30 Jun
2023
Seminar
11h-23h
Predictive models of stochasticity in cancer immunotherapy: from single lymphocytes to global inflammation
and back
to be completed soon
20 Jun
2023
Seminar
11h-23h
Understanding immune aging in mice and humans
Dr. Artyomov will present his work in immune aging where his laboratory using characterized immune aging in mouse tissues identifying GZMK+ CD8 T cells as uniform hallmark of aging. In parallel effort profiling of human circulating immune cells revealed existence of dedicated GZMK+ CD8 effector memory T cells in the peripheral blood that accumulate with age. We will discuss their transcripti
14 Jun
2023
Institutional seminar "Mayent - Rothschild"
11h-13h
Type I IFNs in health and disease: from trisomy 21 to cancer
Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the development of innate and adaptive immune responses. We will discuss our results by addressing the biology of IFN in Down syndrome (DS). This syndrome is the consequence of a chromosomal anomaly known as "trisomy 21" in which chromosome 21 is partially or totally tripled. The subunits that make up
14 Jun
2023
Institutional seminar "Mayent - Rothschild"
11h-23h
Lessons from COVID-19 vaccines: high dimensional analyisis of specific T and B cell immune response reveals distinct immunological signatures in 16 combinations of vaccines
The range of vaccines developed against SARS-CoV-2 gave a unique opportunity to study immunization across different platforms. In a single-center cohort with more than 400 volunteers, we analysed the humoral and cellular immune compartments following five COVID-19 vaccines spanning three technologies (adenoviral, mRNA, and inactivated-virus) administered in 16 combinations. Quantification of speci