Unit
Immunity and Cancer (U932)
Thematic areas of research:
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Unit
ANA-MARIA LENNON DUMENIL / OLIVIER LANTZ
Immunity and Cancer (U932)
Created in 2005, the INSERM U932 Unit is composed of 10 teams, spread over two buildings (Hôpital Curie and Constant-Burg building, rue Lhomond), with a total of about 120 people.
Teams
Key figures
334
publication since 2017
11
ERC since 2008
3
start-ups
Key publications
All publications
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Constitutive Siglec-1 expression confers susceptibility to HIV-1 infection of human dendritic cell precursorsProceedings of the National Academy of Sciences
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Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activationJournal of Experimental Medicine
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News
All news
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Promising results from Institut Curie presented at the AACR congressFrom April 5 to 10 2024 in San Diego (United States), the scientific community and medical community will be meeting for the annual congress of the American Association for Cancer Research. This is an opportunity for Institut Curie researchers and doctors to present their advances in the various fields of cancer research.05/04/2024
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Un nouveau projet d’envergure pour comprendre et combattre le mélanome uvéalL’Institut Curie a lancé en septembre dernier un projet ambitieux dans la lutte contre le mélanome uvéal, le cancer de l’œil le plus fréquent chez l’adulte. En collaboration avec le Melanoma Patients Network Europe (MPNE) et soutenu par le Secrétaire adjoint américain à la défense pour les affaires sanitaires et approuvé par le ministère américain de la Défense, le projet a pour objectifs d’identifier la prédisposition génétique, la tumorigenèse ainsi que les réponses immunitaires spécifiques à ce cancer.31/10/2023
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The key role of “junk” DNA in the exhaustion of T cells in cancerIt was believed for a long time that half of the genome served no purpose. So such an extent that we talked about “junk” DNA when referring to these “transposable elements” 1that repeat in the host genome in a dispersed manner. Researchers at Institut Curie, CNRS and Inserm have just shown that the expression of these elements changes completely during the course of the phenomenon known as “exhaustion” of certain cells of the immune system (T cells) that occur in cancers. This discovery, published in the journal Science Immunology on October 27, 2023, offers new prospects for immunotherapy.22/11/2023
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Contrecarrer les effets du vieillissement et l’apparition des cancers : de nouveaux résultats prometteursCancer et vieillissement sont des processus intimement liés et pourtant, les mécanismes au cœur de cette relation demeurent assez méconnus. En étudiant les cellules immunitaires dans le poumon, des chercheurs de l’Institut Curie et de l’Inserm ont apporté de nouvelles connaissances sur le sujet. Ils révèlent notamment que cibler les ruptures de l’enveloppe nucléaire de ces cellules représenterait une nouvelle opportunité d’intervention thérapeutique dans les maladies liées à l’âge, notamment le cancer, améliorant ainsi la qualité de vie des personnes âgées sur le long terme. Financés par la Fondation ARC, ces travaux viennent d’être publiés dans la revue Nature Aging.22/09/2023
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Immunotherapy, a new ally against cervical cancer?Could chemoradiotherapy in combination with immunotherapy help fight cervical cancer? To start to answer the question, a team from Institut Curie conducted a phase-I clinical trial. The results, published in Nature Communications, do not simply reveal good tolerance for the treatment, but they also highlight the biomarkers predictive of its efficacy.07/09/2023
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Manger des brocolis pour limiter les allergies cutanéesLa sévérité des allergies cutanées peut varier en fonction de nombreux facteurs environnementaux, et notamment du régime alimentaire. Cependant, jusqu’à présent, la contribution de nutriments spécifiques n’avait pas été bien documentée. Dans une nouvelle étude, des chercheurs et chercheuses de l’Inserm et de l’Institut Curie ont montré que l’absence dans l’alimentation de composés que l’on retrouve dans certains légumes, en particulier les brocolis et les choux, pouvait aggraver les allergies cutanées dans des modèles animaux.17/05/2023
Scientific events
All scientific events
16 Sep
2024
Seminar Immunology series
11h-23h
When Nuance Matters: The lesser known side of PD1 signaling
The inhibitory immunoreceptor PD1 is a major cancer immunotherapy target. Anti-PD1 blockade antibodies have become the standard of care for cancer patients, but the low response rate and associated immune related side effects necessitate a better understanding of PD1 mechanism. Best known to be expressed by T cells, PD1 transduces inhibitory signals to attenuate T cell response upon binding to its
10 Sep
2024
Seminar
14h-23h
B cell memory in barrier tissues - " From the bench to the bedside: cancer immunotherapy with soluble T cell receptors"
B cell memory in barrier tissues
During infection, the immune system unleashes protective responses to fight against the pathogen while also establishes a memory compartment that will provide protection in case of a subsequent pathogen encounters. The B cell memory compartment is composed of two layers: long-lived plasma cells (LLPCs) and memory B cells (MBCs). LLPCs mainly migrate to the bone
During infection, the immune system unleashes protective responses to fight against the pathogen while also establishes a memory compartment that will provide protection in case of a subsequent pathogen encounters. The B cell memory compartment is composed of two layers: long-lived plasma cells (LLPCs) and memory B cells (MBCs). LLPCs mainly migrate to the bone
10 Jun
2024
Seminar
11h-23h
Functional and molecular characterization of cancer-derived extracellular vesicles
Cancer-derived extracellular vesicles have been demonstrated to play a crucial role in cancer biology. Our team is particularly interested in cancer EV heterogeneity and we have been studying a particular population of extracellular vesicles, known as large oncosomes. These EVs are released by aggressive cancer cells that exhibit cell plasticity and have acquired metastatic abilities. I will
21 May
2024
Seminar
11h-23h
Nucleosomes and DNA methylation implications for immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome and cancers
DNA methylation is a broadly observed epigenetic modification. As genomic DNA methylation profiles dynamically change during development and aging, alterations in DNA methylation patterns are linked to diseases such as cancers and immunodeficiency. ICF syndrome is characterized by hypomethylation at heterochromatin. Of four proteins whose mutation cause ICF syndromes (DNMT3B, ZBTB24, CDCA7 and HEL
13 May
2024
Seminar
11h-23h
Deconstruct-Reconstruct Decode cancer-immune crosstalk & probe with organoids.
The Roose team at UCSF studies mechanisms of cell-cell interactions in immunology and cancer1-7, with emphasis on personalized medicine4,8 and single cell approaches9-11. Over the past 7 years, we shifted a large portion of our research efforts to understanding human biology and disease. We are deeply interested in the cellular networks that underpin autoimmune diseases and cancer, which I will ta