Developing an advanced gut on chip model enabling the study of epithelial cell/fibroblast interactions

Lab on a Chip
Marine Verhulsel, Anthony Simon, Moencopi Bernheim-Dennery, Venkata Ram Gannavarapu, Lauriane Gérémie, Davide Ferraro, Denis Krndija, Laurence Talini, Jean-Louis Viovy, Danijela Matic Vignjevic, Stéphanie Descroix
DOI
10.1039/d0lc00672f
Abstract

We report on a new gut on chip combining the co-culture of primary epithelial and stromal cells in 3D biomimetic scaffold. Proper segregation of dividing and differentiated cells along the crypt-villus axis was achieved in these unique conditions.

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