• Home >
  • Publications >
  • Transduction channels' gating can control friction on vibrating hair-cell bundles in the ear

Transduction channels' gating can control friction on vibrating hair-cell bundles in the ear

20 May 2014Proceedings of the National Academy of Sciences

DOI : 10.1073/pnas.1402556111

Authors

V. Bormuth, J. Barral, J.-F. Joanny, F. Julicher, P. Martin

Abstract

Significance

In this work, we developed a dynamic force assay to characterize frictional forces that impede sound-evoked vibrations of hair-cell bundles, the mechanosensory antennas of the inner ear. We find that opening and closing of mechanosensitive ion channels in the hair bundle produce frictional forces that can dominate viscous drag on the hair-bundle structure. We show that channel friction can be understood quantitatively using a physical theory of hair-bundle mechanics that includes channel kinetics. Friction originating from gating of ion channels is a concept that is relevant to all mechanosensitive channels. In the context of hearing, this channel friction may contribute to setting the characteristic frequency of the hair cell.

Members

PASCAL MARTIN

Directeur de recherche CNRS