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9 result(s)

2025Development of clinically viable non-muscle myosin II small molecule inhibitorsCell
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2024Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathyNature Cardiovascular Research
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2024Omecamtiv mecarbil and Mavacamten target the same myosin pocket despite opposite effects in heart contractionNature Communications
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2023How myosin VI traps its off-state, is activated and dimerizesNature Communications
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2023Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug designNature Communications
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2023Cryo-EM structure of the folded-back state of human β-cardiac myosinNature Communications
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2021The many roles of myosins in filopodia, microvilli and stereociliaCurrent Biology
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2020Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle StiffnessCell
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2020Force Generation by Myosin Motors: A Structural PerspectiveChemical Reviews
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