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Team

Alternative DNA repair mechanisms in human cancers

RAPHAEL CECCALDI

Team Leader

Unit :

Chemical Biology of Cancer (UMR3666 / U1339)

Presentation

Our goal is to understand DNA repair mechanisms that are essential for the survival of cancer cells. Unraveling the function and structure of these mechanisms will facilitate the identification of new targets for the tailored treatment of cancer.

Publications

2023DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C

Molecular Cell - 01/10/2023

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2023Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis

Nature - 14/09/2023

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2021A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors

Nature Cancer - 01/06/2021

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2016FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

Cell Reports - 01/06/2016

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2016Repair Pathway Choices and Consequences at the Double-Strand Break

Trends in Cell Biology - 01/01/2016

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2015Homologous Recombination Deficiency: Exploiting the Fundamental Vulnerability of Ovarian Cancer

Cancer Discovery - 01/11/2015

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2015Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

Nature - 12/02/2015

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Life of the team

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