DNA Repair, Radiations and Innovative Cancer Therapies

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Team

ARTURO LONDONO

DNA Repair, Radiations and Innovative Cancer Therapies

Our team develop new antitumoral therapies associated to radio- and/or chemo-therapy to fight cancer resistance to treatment while limiting adverse effects.

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Members

ARTURO LONDONO

Research Unit Director

MARIE DUTREIX

Researcher Emeritus

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DELPHINE JAVELAUD

Permanent Researcher

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CHARLES FOUILLADE

Scientific Project Manager

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JULIETTE SOULIER

PhD Student

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Our Projects

Development and functional characterization of molecules that radio-sensitize tumors and/or protect healthy tissue from radiation

Study of the interaction between the DNA-PK complex and the GLI2 transcription factor

Key publications

2023

Lung Organotypic Slices Enable Rapid Quantification of Acute Radiotherapy Induced Toxicity
Cells

Maxime Dubail, Sophie Heinrich, Lucie Portier, Jessica Bastian, Lucia Giuliano, Lilia Aggar, Nathalie Berthault, José-Arturo Londoño-Vallejo, Marta Vilalta, Gael Boivin, Ricky A. Sharma, Marie Dutreix, Charles Fouillade
(2023 11 Oct)
2023

An interactive murine single-cell atlas of the lung responses to radiation injury
Nature Communications

Sandra Curras-Alonso, Juliette Soulier, Thomas Defard, Christian Weber, Sophie Heinrich, Hugo Laporte, Sophie Leboucher, Sonia Lameiras, Marie Dutreix, Vincent Favaudon, Florian Massip, Thomas Walter, Florian Mueller, José-Arturo Londoño-Vallejo, Charles Fouillade
(2023 28 Apr)
2023

Characterization of Ultra-High-Dose Rate Electron Beams with ElectronFlash Linac
Applied Sciences

Lucia Giuliano, Gaia Franciosini, Luigi Palumbo, Lilia Aggar, Marie Dutreix, Luigi Faillace, Vincent Favaudon, Giuseppe Felici, Federica Galante, Andrea Mostacci, Mauro Migliorati, Matteo Pacitti, Annalisa Patriarca, Sophie Heinrich
(2023 03 Jan)
2022

Perspectives in linear accelerator for FLASH VHEE: Study of a compact C-band system
Physica Medica

L. Faillace, D. Alesini, G. Bisogni, F. Bosco, M. Carillo, P. Cirrone, G. Cuttone, D. De Arcangelis, A. De Gregorio, F. Di Martino, V. Favaudon, L. Ficcadenti, D. Francescone, G. Franciosini, A. Gallo, S. Heinrich, M. Migliorati, A. Mostacci, L. Palumbo, V. Patera, A. Patriarca, J. Pensavalle, F. Perondi, R. Remetti, A. Sarti, B. Spataro, G. Torrisi, A. Vannozzi, L. Giuliano
(2022 01 Dec)
2022

Inhibition of DNA Repair by Inappropriate Activation of ATM, PARP, and DNA-PK with the Drug Agonist AsiDNA
Cells

Nathalie Berthault, Ptissam Bergam, Floriane Pereira, Pierre-Marie Girard, Marie Dutreix
(2022 08 Jul)
2020

AsiDNA Is a Radiosensitizer with no Added Toxicity in Medulloblastoma Pediatric Models
Clinical Cancer Research

Sofia Ferreira, Chloe Foray, Alberto Gatto, Magalie Larcher, Sophie Heinrich, Mihaela Lupu, Joel Mispelter, François D. Boussin, Célio Pouponnot, Marie Dutreix
(2020 01 Nov)
2020

FLASH Irradiation Spares Lung Progenitor Cells and Limits the Incidence of Radio-induced Senescence
Clinical Cancer Research

Charles Fouillade, Sandra Curras-Alonso, Lorena Giuranno, Eddy Quelennec, Sophie Heinrich, Sarah Bonnet-Boissinot, Arnaud Beddok, Sophie Leboucher, Hamza Umut Karakurt, Mylène Bohec, Sylvain Baulande, Marc Vooijs, Pierre Verrelle, Marie Dutreix, Arturo Londoño-Vallejo, Vincent Favaudon
(2020 15 Mar)
2019

AsiDNA Treatment Induces Cumulative Antitumor Efficacy with a Low Probability of Acquired Resistance
Neoplasia

Wael Jdey, Maria Kozlak, Sergey Alekseev, Sylvain Thierry, Pauline Lascaux, Pierre-Marie Girard, Françoise Bono, Marie Dutreix
(2019 01 Sep)

All publications

News

Improved understanding of the molecular mechanisms of the side effects caused by radiotherapy

Although radiotherapy saves increasing numbers of cancer patients, at the same time we are seeing more side effects. A team from Institut Curie sought to better understand the mechanisms of lesions caused by this gold standard treatment.

15/06/2023

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