Unit
Signaling, radiobiology and cancer (UMR3347 / U1021)
Thematic areas of research:
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Unit
ARTURO LONDONO / LIONEL LARUE
Signaling, radiobiology and cancer (UMR3347 / U1021)
The cornerstone of our unit’s research thematic is its integrative view of molecular and cellular knowledge in a physiopathological context, ultimately favoring the development of innovative treatments for cancer. The unit, located on the Orsay site of the Institut Curie Research Center, has a significant critical mass, and the focusing of its interests on a main axis of research lead to the development of synergy and foster innovation and creativity
Teams
Key figures
25
publications in 2020
2
ongoing ERC in 2020
16
PhD students in 2020
Key publications
All publications
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X-rays minibeam radiation therapy at a conventional irradiator: Pilot evaluation in F98-glioma bearing rats and dose calculations in a human phantomClinical and Translational Radiation Oncology
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AsiDNA Is a Radiosensitizer with no Added Toxicity in Medulloblastoma Pediatric ModelsClinical Cancer Research
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News
All news
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Improved understanding of the molecular mechanisms of the side effects caused by radiotherapyAlthough radiotherapy saves increasing numbers of cancer patients, at the same time we are seeing more side effects. A team from Institut Curie sought to better understand the mechanisms of lesions caused by this gold standard treatment.15/06/2023 -
Yolanda Prezado, Carsten Janke, Céline Vallot et Nicolas Manel récompensés par l’Académie des sciencesLe 23 novembre, l’Académie des sciences a remis, lors d'une cérémonie exceptionnelle sous la coupole de l’Institut de France, l’ensemble des prix et médailles qu’elle a attribués en 2021. Quatre chercheurs et médecins de l’Institut Curie ont été distingués. Toutes nos félicitations !25/11/2021 -
Rétinoblastome : un projet ambitieux pour préserver la vision des enfantsL’Institut Curie, centre de référence pour le rétinoblastome, cancer pédiatrique de l’œil le plus fréquent, s’apprête à démarrer un projet de recherche pluridisciplinaire qui impliquera plusieurs de ses équipes de recherche et services hospitaliers.18/11/2021 -
FHL3: A Scaffold Protein, Architect of the Embryonic Nervous SystemThe various signals that orchestrate the first notes of the concerto that is the nervous system are part of a very complex score! Even so, researchers from Institut Curie, CNRS, Inserm, and Université Paris-Saclay* have managed to decipher the role played by FHL3, a modulator that precisely regulates the information interpreted by the cells. Their work was published in Cell Report.30/07/2021
Scientific events
All scientific events
1 Jul
2024
Seminar
14h-23h
Tumor-associated monocytes and neutrophils: Targets for immunotherapy?
Our goal is to better understand the immune microenvironment in cancers using advanced methodologies, including in vivo imaging and single-cell genomics. In particular, we aim to unveil the immense potential of myeloid populations in cancers, an emerging field. Real-time intravital multi-photon microscopy provides insight into dynamic cell migration and intercellular communication. We reveal
8 Mar
2024
Seminar
11h-23h
Solar radiation and pollution: a mitochondrial perspective.
Although the mitochondrion is central to the genotoxic stress response, it has not received the attention commensurate with its importance. Thanks to the development of novel methods for isolating and internalizing functional mitochondria as well as techniques to analyze their condition, we can now better advance our knowledge on the subject. With increasing evidence of the toxic synergy between U
20 Dec
2023
Seminar
11h-23h
Modeling of MYC-driven malignant pediatric brain tumors and novel treatment options
Fredrik Swartling is currently a Group Leader, Senior Lecturer and Associate Professor in pediatric brain tumor biology at Uppsala University. A particular focus of his lab is on generating sophisticated inducible transgenic models for molecularly-defined brain tumors or avatar models and organoids derived from human primary neuroepithelial or induced-pluripotent stem cells. The lab also uses mult
20 Apr
2023
Seminar
11h-12h
Acute and chronic endothelial cell responses modulate radiation therapy efficacy.
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25 Oct
2022
Seminar
10h-12h
"Role of innate-immune response and micro-environment on regenerative potential of salivary glands after photon and proton irradiation."