The hosting structure
The Curie Institute Research Center
The “Institut Curie” is a major player in the research and fight against cancer. It consists of a hospital and a Research Center of more than 1000 employees with a strong international representativeness.
The objective of the Curie Institute Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.
Job description
Laboratory
The Integrative Functional Genomics of Cancer team (U1330, Institut Curie) is dedicated exclusively to the bioinformatic and computational analysis of interactions between tumors and the immune system. Using large-scale genomics approaches and single-cell technologies (scRNA-seq, scATAC-seq, scTCR-seq), it explores immune infiltrates, identifies new tumor antigens, and studies non-genetic mechanisms of immunogenicity, particularly in pediatric cancers and sarcomas. The team integrates data from patients, experimental models, and large public databases (TCGA, GTEx, TARGET, ICGC) with the aim of producing analyses with high translational and clinical impact, without experimental laboratory activity.
Missions
You will optimize pipelines for analysis of tumor NGS profiling and contribute to the development of a web platform designed to provide the scientific and industrial community with a tool for searching for unconventional transcriptomic sequences, based on technologies developed within the laboratory. As part of this project, you will be required to :
- Optimize pipelines for integrated Whole Exome sequencing and RNAseq of tumor samples from Curie Hospital
- Develop, maintain, and improve the software chain related to the web platform (Snakemake pipelines, Python scripts, etc.); respond to the needs and feedback expressed by platform users. Deploy the software chain on the cluster nodes dedicated to the platform.
- Maintain and improve the software tools used by the team to search for transcriptomic sequences.
- Update the necessary elements on the platform's website; liaise with the service provider responsible for the webapp; possibly make some minor corrections (no experience in webdev development is expected).
Develop and implement, in conjunction with the relevant departments, a strategy to develop and expand the community of users of the web platform.
Candidate Profile
Training and experience required
- Level 7 Master's degree/equivalent qualifications
- Professional experience in data science or computer science
Skills required
- Solid experience in programming, design patterns, Python 3, git
- Good knowledge of Linux systems (including command line)
- Autonomy, initiative, and rigor, good analytical and synthesis skills
- Ability to work in a team, particularly in a multidisciplinary scientific environment
- Ability to work in English
- Proficiency in written and oral presentation techniques
All our opportunities are open to people with disabilities
Contract information
Type of contract: Fixed-term contract
Starting date: 15 October 2025
Duration: 18 months
Working time: full time
Remuneration: according to the current grids
Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance
Location of the position: Paris
Contact
Please send your CV, letter of motivation and 2 references, to
Publication date: 1st September 2025
Deadline for application: 15 October 2025
Institut Curie is an inclusive, equal opportunity employer
and is dedicated to the highest standards of research integrity.
https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf