The Chromatin Dynamics Team (UMR 3664-CNRS), led by Dr G. Almouzni, explores how chromatin organization from its elementary bricks (histone variants and nucleosomes) up to chromosomal landmarks and nuclear architecture functionally contributes and adapts to cell physiology https://institut-curie.org/team/almouzni).
We aim to define the molecular interactions between histone chaperones and histone variants and how they act as a regulated flexible network to assemble, maintain or change chromatin states during normal (development, differentiation) and pathological (cancer) changes of cell fate. We combine biological models from cells to tissue with approaches involving biochemistry, omics and imaging.
The project explores the 3D spatial chromatin organization in cells undergoing changes of fate in cell cycle and differentiation. Chromatin regulators, histone variants and DNA transactions such as replication, transcription and repair will be examined, along with chromosomal loci and landmarks (eu/heterochromatin) from normal to pathological states.
Training and experience required
Motivated Candidate should be trained in cell biology with expertise in ES cells / 3D cell culture (organoids/embryoids). Know-how of sample preparation and acquisition of Super-Resolution images is valued. Experience in data processing for imaging and physical parameters is a plus.
Successful candidate will join the SuperES consortium within an international team with post-doctoral researchers, PhDs students supported by experienced staff scientists, in a vibrant scientific community at the Institut Curie in Paris. Access to multidisciplinary approaches, new technologies and advanced training programs, career development and networking opportunities is provided.
- Autonomy and organizational capacity
- Scientific rigor and transparency
- Editorial qualities
- Ability and willingness to work in an international and multicultural team
- Interpersonal skills.
All our opportunities are open to people with disabilities.
Type of contract: Fixed-term contract
Starting date: As soon as possible
Duration: 2 years (renewable)
Working time: full time
Remuneration: According to the current grids
Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance
Location of the position: Paris
Please send your CV, letter of motivation and 2 references, to firstname.lastname@example.org.
Publication date: December 5th, 2023
Deadline for application: May 31st, 2023
Institut Curie is an inclusive, equal opportunity employer
and is dedicated to the highest standards of research integrity.