SYLVIE COSCOY

PI of the Doctoral Group "Geometrical and mechanical determinants of multicellular behaviors: renal cyst formation and vascular organization in microfabricated environments", ED394 Physiology, Physiopathology and Therapeutics, SU.

Project "Formation and propagation of renal cysts: study in biomimetic deformable microfluidic devices"

Coordinated since 2015, collaborations Stéphanie Descroix (MMBM, UMR168), and Frank Bienaimé, Sophie Saunier, Marco Pontoglio, Fabiola Terzi (Necker hospital). Two PhD defended.

Keywords : kidney-on-chip; ADPKD (Autosomal Dominant Polycystic Kidney Disease); microfabrication, microfluidics; renal cysts.

Project "Dynamic cell-matrix interactions in the context of the tumor microenvironment: study in an innovative system of 3D controlled fiber arrays."

Coordinated since 2022, collaborations Vincent Semetey (ChimieParistech), Hélène Moreau (U932) and Catherine Monnot (CRC). One PhD defended, three PhD in progress.

Keywords: Two-photon polymerization , Extracellular matrix , Tumor microenvironment , Cytoskeleton, Mechanical forces , Mechanotransduction