ANNE-LAURE LE GAC

Doctor

Recherche - Paris

Spécialités / domaines

Bioinformatics,

Epigenetics,

Basic research,

Single Cell

Functions within Institut Curie:

Bioinformatic Scientist

Innate Like and CD4 T Cells in Cancer
Unit : Immunity and Cancer (U932)

Présentation

Bioinformatic post-doc

Multi-omic analysis of single cell data set going from scRNA-se, scTCR-seq, scATAC-seq, bulk RNA-seq

Some of the analysis developp to answer the different biologicals questions: integrations, trajectory, annotation, GRN, TF erichment...

Publications

2024

Divergent local and systemic antitumor response in primary uveal melanomas

Journal of Experimental Medicine

Francesca Lucibello, Ana I. Lalanne, Anne-Laure Le Gac, Abdoulaye Soumare, Setareh Aflaki, Joanna Cyrta, Lea Dubreuil, Martin Mestdagh, Marion Salou, Alexandre Houy, Christina Ekwegbara, Camille Jamet, Sophie Gardrat, Anais Le Ven, Karine Bernardeau, Nathalie Cassoux, Alexandre Matet, Denis Malaise, Gaelle Pierron, Sophie Piperno-Neumann, Marc-Henri Stern, Manuel Rodrigues, Olivier Lantz

(2024 03 Jun)

2024

Innate-like T cell subset commitment in the murine thymus is independent of TCR characteristics and occurs during proliferation

Proceedings of the National Academy of Sciences

Vadim K. Karnaukhov, Anne-Laure Le Gac, Linda Bilonda Mutala, Aurélie Darbois, Laetitia Perrin, Francois Legoux, Aleksandra M. Walczak, Thierry Mora, Olivier Lantz

(2024 02 Apr)

2024

A conserved transcriptional program for MAIT cells across mammalian evolution

Journal of Experimental Medicine

Hélène Bugaut, Yara El Morr, Martin Mestdagh, Aurélie Darbois, Rafael A. Paiva, Marion Salou, Laetitia Perrin, Mariela Fürstenheim, Anastasia du Halgouet, Linda Bilonda-Mutala, Anne-Laure Le Gac, Manon Arnaud, Ahmed El Marjou, Coralie Guerin, Atitheb Chaiyasitdhi, Julie Piquet, David M. Smadja, Agata Cieslak, Bernhard Ryffel, Valdone Maciulyte, James M.A. Turner, Karine Bernardeau, Xavier Montagutelli, Olivier Lantz, François Legoux

(2024 05 Feb)