Image

FRANCOIS RADVANYI

Doctor,
Directeur de recherche
Recherche - Paris
Spécialités / domaines
Multi-scale physics-chemistry-biology and cancer (molecules, cells, tissues and organisms)
Functions within Institut Curie:
Présentation

François Radvanyi is a research director at CNRS, specializing in the genetics and epigenetics of cancer. His approach combines bioinformatics and experimental validation.

He completed his thesis at the Pasteur Institute under the direction of Cassian Bon and a post-doctoral internship at the Hormone Research Institute, UCSF, San Francisco under the direction of Douglas Hanahan. His team, initially created within the unit of Jean Paul Thiery at ENS, is now located at the Curie Institute (Molecular Oncology Team, UMR 144 CNRS).

The cancers studied by the team include a common adult cancer, bladder cancer, and a pediatric cancer treated at the Curie Institute, retinoblastoma. Their work is multidisciplinary and involves MDs, biologists, epidemiologists, and bioinformaticians.

Some of their notable results include the identification of key genes in bladder cancers, such as the FGFR3, EGFR, and TYRO3 tyrosine kinase receptors, and the PPARG nuclear receptor; characterization of bladder cancer subtypes, particularly the basal subtype; and characterization of an aggressive subset of retinoblastoma. Their discoveries have led to several clinical applications.

Publications
Proteogenomic Characterization of Bladder Cancer Reveals Sensitivity to Apoptosis Induced by Tumor Necrosis Factor–related Apoptosis-inducing Ligand in FGFR3-mutated Tumors
European Urology
Clarice S. Groeneveld, Virginia Sanchez-Quiles, Florent Dufour, Mingjun Shi, Florent Dingli, Rémy Nicolle, Elodie Chapeaublanc, Patrick Poullet, Daniel Jeffery, Clémentine Krucker, Pascale Maillé, Francis Vacherot, Dimitri Vordos, Simone Benhamou, Thierry Lebret, Olivier Micheau, Andrei Zinovyev, Damarys Loew, Yves Allory, Aurélien de Reyniès, Isabelle Bernard-Pierrot, François Radvanyi
Epigenomic mapping identifies an enhancer repertoire that regulates cell identity in bladder cancer through distinct transcription factor networks
Oncogene
Hélène Neyret-Kahn, Jacqueline Fontugne, Xiang Yu Meng, Clarice S. Groeneveld, Luc Cabel, Tao Ye, Elodie Guyon, Clémentine Krucker, Florent Dufour, Elodie Chapeaublanc, Audrey Rapinat, Daniel Jeffery, Laura Tanguy, Victoria Dixon, Yann Neuzillet, Thierry Lebret, David Gentien, Irwin Davidson, Yves Allory, Isabelle Bernard-Pierrot, François Radvanyi
FGFR3 Mutational Activation Can Induce Luminal-like Papillary Bladder Tumor Formation and Favors a Male Sex Bias
European Urology
Ming-Jun Shi, Jacqueline Fontugne, Aura Moreno-Vega, Xiang-Yu Meng, Clarice Groeneveld, Florent Dufour, Aurélie Kamoun, Sia Viborg Lindskrog, Luc Cabel, Clémentine Krucker, Audrey Rapinat, Claire Dunois-Larde, May-Linda Lepage, Elodie Chapeaublanc, Olivier Levrel, Victoria Dixon, Thierry Lebret, Anna Almeida, Aurélien De Reynies, Natacha Rochel, Lars Dyrskjøt, Yves Allory, François Radvanyi, Isabelle Bernard-Pierrot
Multilayer spectrum of intratumoral heterogeneity in basal bladder cancer
The Journal of Pathology
Nanor Sirab, Damien Drubay, Pascale Maillé, Tatiana Popova, Carine Ngo, David Gentien, Anissa Moktefi, Pascale Soyeux‐Porte, Romain Pelletier, Cécile Reyes, Emilie Henry, Damien Pouessel, Dimitri Vordos, Thierry Lebret, Aurélien Reyniès, Xavier Paoletti, François Radvanyi, Yves Allory
A high-risk retinoblastoma subtype with stemness features, dedifferentiated cone states and neuronal/ganglion cell gene expression
Nature Communications
Jing Liu, Daniela Ottaviani, Meriem Sefta, Céline Desbrousses, Elodie Chapeaublanc, Rosario Aschero, Nanor Sirab, Fabiana Lubieniecki, Gabriela Lamas, Laurie Tonon, Catherine Dehainault, Clément Hua, Paul Fréneaux, Sacha Reichman, Narjesse Karboul, Anne Biton, Liliana Mirabal-Ortega, Magalie Larcher, Céline Brulard, Sandrine Arrufat, André Nicolas, Nabila Elarouci, Tatiana Popova, Fariba Némati, Didier Decaudin, David Gentien, Sylvain Baulande, Odette Mariani, Florent Dufour, Sylvain Guibert, Céline Vallot, Livia Lumbroso-Le Rouic, Alexandre Matet, Laurence Desjardins, Guillem Pascual-Pasto, Mariona Suñol, Jaume Catala-Mora, Genoveva Correa Llano, Jérôme Couturier, Emmanuel Barillot, Paula Schaiquevich, Marion Gauthier-Villars, Dominique Stoppa-Lyonnet, Lisa Golmard, Claude Houdayer, Hervé Brisse, Isabelle Bernard-Pierrot, Eric Letouzé, Alain Viari, Simon Saule, Xavier Sastre-Garau, François Doz, Angel M. Carcaboso, Nathalie Cassoux, Celio Pouponnot, Olivier Goureau, Guillermo Chantada, Aurélien de Reyniès, Isabelle Aerts, François Radvanyi
Molecular diagnosis of retinoblastoma by circulating tumor DNA analysis
European Journal of Cancer
Irene Jiménez, Éléonore Frouin, Mathieu Chicard, Catherine Dehainault, Jessica Le Gall, Camille Benoist, Arnaud Gauthier, Eve Lapouble, Claude Houdayer, François Radvanyi, Virginie Bernard, Hervé J. Brisse, Marion Gauthier-Villars, Dominique Stoppa-Lyonnet, Sylvain Baulande, Nathalie Cassoux, Livia Lumbroso, Alexandre Matet, Isabelle Aerts, Victor Renault, François Doz, Lisa Golmard, Olivier Delattre, Gudrun Schleiermacher