Unit
Cell Biology and Cancer (UMR144)
Thematic areas of research:
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Unit
FRANCK PEREZ / RENATA BASTO
Cell Biology and Cancer (UMR144)
The mission of this unit is to understand the biogenesis of the cell compartments and the molecular mechanisms that govern normal cellular functions.
The main research themes of the unit include:
- Transport pathways between compartments,
- The dynamics of the actin- and microtubule-based cytoskeletons,
- Three-dimensional structures of molecular motors,
- Mechanisms of cell division and cell migration,
- The mechanisms involved in establishing the polarity of epithelia and their differentiation,
- Signalling pathways associated with tumour progression in several mouse models and human tumours,
- Regulation of adhesive systems during morphogenesis and development.
Teams
Key figures
165
members in 2020
34
PhD students in 2020
82
publications in 2020
Key publications
All publications
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Force Generation by Myosin Motors: A Structural PerspectiveChemical Reviews
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RAB6 and microtubules restrict protein secretion to focal adhesionsJournal of Cell Biology
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News
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Nikon Imaging Center @Institut Curie-CNRS : une plateforme d’imagerie scientifique unique en FranceL’Institut Curie, le CNRS et Nikon annoncent le renouvellement de leur partenariat autour de leur plateforme d’imagerie scientifique de pointe : le Nikon Imaging Center @Institut Curie-CNRS. Unique centre d’imagerie scientifique de cette envergure en France, la plateforme célèbre, en 2022, ses 15 ans au service de la recherche fondamentale, biomédicale, et de l’innovation dans le domaine de la microscopie optique.13/05/2022
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Quand la duplication du génome génère de l’instabilité génétique en une seule phase SUne duplication du génome a été retrouvée dans environ 40% des tumeurs, participant à générer de l’instabilité génétique selon un mécanisme encore peu compris.01/04/2022
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UNDERSTAND THE ARCHITECTURE AND ORGANIZATION OF CENTROMERESConducted at the Institut Curie, Daniele Fachinetti's team's work, Molecular Mechanisms of Chromosome Dynamics, represents a significant advance in our understanding of the basic architecture and molecular organization of human centromeres.22/03/2022
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Michel Bornens, a historic pillar of the Research CenterA biologist specializing in the centrosome, co-founder in 1995 of the mixed research center dedicated to the cell and the cooperative Physics and Biology program at Institut Curie, Michel Bornens passed away on March 6, 2022, at the age of 84. Michel Bornens had been a long-term member of Institut Curie’s Board of Directors as staff representative.14/03/2022
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Rétinoblastome : un projet ambitieux pour préserver la vision des enfantsL’Institut Curie, centre de référence pour le rétinoblastome, cancer pédiatrique de l’œil le plus fréquent, s’apprête à démarrer un projet de recherche pluridisciplinaire qui impliquera plusieurs de ses équipes de recherche et services hospitaliers.18/11/2021
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Deciphering centromeres to understand how cancer cells developCentromeres are, in most of the cases in humans, the center of our chromosomes and play an essential role in the conservation of our genetic makeup during cell division. Changes to this process can cause cell transformation and, ultimately, can allow cancer to develop.03/03/2021
Scientific events
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31 May
2022
Seminar Cell Biology Series
11h-23h
Mechano-Immunology: Novel mechanical routes to drive inflammatory epigenomic programs
Nikhil Jain is a Birmingham Fellow working across the Institutes of Inflammation and Ageing, and the School of Chemical Engineering. Nikhil is a cell engineer who specializes in mechanobiology and developing novel bioengineering tools and techniques and combining them with cutting-edge epi-imaging, and advanced “omics” to tackle challenging questions in human h
13 May
2022
Seminar Cell Biology Series
10h-11h
Making and measuring macromolecular machines
ZOOM Link: https://cnrs.zoom.us/j/99156743042?pwd=K3FLMFc2cUd4N3VMY0gvbnRIT2V1Zz09
ID meeting : 991 5674 3042
Code secret : vZ82GN
Molecular machines lie at the heart of biological processes ranging from DNA replication to cell migration. We use single-molecule tracking and manipulation to characterize the structural dynamics of these nanoscale assemblies, and further challenge our unders
ID meeting : 991 5674 3042
Code secret : vZ82GN
Molecular machines lie at the heart of biological processes ranging from DNA replication to cell migration. We use single-molecule tracking and manipulation to characterize the structural dynamics of these nanoscale assemblies, and further challenge our unders
22 Mar
2022
Seminar Cell Biology Series
11h-13h
Investigating cellular logistics with live-cell STED super-resolution microscopy
In the lab we use gene editing and live-cell super-resolution microscopy to study the mechanisms of membrane homeostasis in health and disease. To be able to image physiological molecular processes in the crowded cellular cytoplasm in living cells, we developed labelling methods for stimulated emission depletion (STED) super-resolution imaging in living cells and a pipeline for the rapid generatio
1 Feb
2022
Seminar Cell Biology Series
11h-13h
Caveolae rings form platforms for Amphiphysin2/Bin1-mediated T-tubule initiation
Caveolae have been proposed to participate in the formation of the T-tubule system in skeletal muscle but to date, mechanistic understanding of the tubulation process per se is cruelly lacking. Here, we developed a two-colour super-resolution and platinum replica correlative electron microscopy technique to visualise caveolae during critical steps of T-tubule formation in extensively differentiate
14 Dec
2021
Seminar Cell Biology Series
11h-13h
Centrosome proteins that link primary ciliogenesis and the DNA damage response
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Job offers
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The Institut Curie is a major player in cancer research and control. It consists of a hospital and a research center with more than 1,000 employees and a strong international presence.
The objective of the Institut Curie Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis and treatment of cancer as part of the continuum between basic research and innovation in the service of patients.
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L'Institut Curie est un acteur majeur de la recherche et de la lutte contre le cancer. Il est composé d'un Groupe Hospitalier et d'un Centre de Recherche de plus de 1000 salariés avec une forte représentativité internationale.
L'objectif du Centre de Recherche est de développer la recherche fondamentale et d'utiliser les connaissances produites pour améliorer le diagnostic, le pronostic et la thérapeutique des cancers dans le cadre du continuum entre recherche fondamentale et innovation au service du patient.
L’Institut Curie est centre de référence pour le rétinoblastome (tous les patients en France atteints de ce cancer sont traités et suivis à l’Institut Curie).
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Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international representativeness.
The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient. It is located on 2 main sites, one in central Paris, the other in Orsay (suburb of Paris). These two sites are easily connected by public transportation with a direct RER line.
The Institut Curie treats and follows all patients in France with retinoblastoma.
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Institut Curie Research Center
Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international representativeness.
The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient. The Institut Curie is comprised 13 outstanding Research Units covering various fields (e.g. epigenetics, immunology, cell biology, chemistry & biology, physics & biology) and 19 cutting-edge technological facilities (e.g. Live imaging, cytometry, electron microscopy, genomics, proteomics).