Unit
Cell Biology and Cancer (UMR144)
Thematic areas of research:
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Unit
FRANCK PEREZ / RENATA BASTO
Cell Biology and Cancer (UMR144)
The mission of this unit is to understand the biogenesis of the cell compartments and the molecular mechanisms that govern normal cellular functions.
The main research themes of the unit include:
- Transport pathways between compartments,
- The dynamics of the actin- and microtubule-based cytoskeletons,
- Three-dimensional structures of molecular motors,
- Mechanisms of cell division and cell migration,
- The mechanisms involved in establishing the polarity of epithelia and their differentiation,
- Signalling pathways associated with tumour progression in several mouse models and human tumours,
- Regulation of adhesive systems during morphogenesis and development.
Teams
Key figures
165
members in 2020
34
PhD students in 2020
82
publications in 2020
Key publications
All publications
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Force Generation by Myosin Motors: A Structural PerspectiveChemical Reviews
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RAB6 and microtubules restrict protein secretion to focal adhesionsJournal of Cell Biology
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News
All news
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Cryomicroscopy: the Research Center thinks bigThe brand new Glacios Cryo-TEM™ by Thermo Fischer was received in February at Institut Curie’s Research Center, This powerful cryo-electron microscope worth over 2 million euros will enable researchers to observe proteins at unprecedented resolution. A new opportunity to understand their function and the alterations responsible for diseases, particularly cancer.17/04/2023 -
Institut Curie certified as Integrated cancer research site for the third timeFollowing a call for applications launched in April 2022, Institut Curie had its integrated cancer research site project certified by France’s Institut national du cancer (Inca). Its goal is to better understand tumor recurrences in order to better prevent, detect and treat them.20/02/2023 -
TEMTIA conference: understanding and targeting EMT to fight metastasesFor its 10th edition, the TEMTIA conference is coming to France for the very first time, taking place at Institut Curie from November 7 to 10. For the event, the two co-chairs of TEMTIA, Prof. Alain Puisieux, Director of the Institut Curie Research Center and Pierre Savagner, Inserm researcher at Gustave Roussy, take a closer look at the challenges surrounding molecular and cellular aspects of the epithelial–mesenchymal transition (EMT) at the root of metastatic cancer progression.09/11/2022 -
Three research projects at Institut Curie financed by the ERC Synergy GrantThree projects at Institut Curie are laureate of the highly selective and prestigious Synergy Grant 2022 program, awarded by the European Research Council. These three grants, for an amount of 10 million euros each, shine a light on Institut Curie’s excellence and its teams in cellular biology. A breakthrough field to further the fight against cancer.28/10/2022 -
Philippe Chavrier, lauréat du Grand prix Ruban Rose 2022Philippe Chavrier, directeur de recherche CNRS et chef d'équipe à l’Institut Curie, est lauréat du Grand Prix Ruban Rose 2022 décerné par l'association Ruban Rose pour son projet novateur sur le développement des comportements invasifs des cellules tumorales, notamment dans les cancers du sein.10/10/2022 -
Manipulating chromosomes in living cells reveals that they are fluidFor the first time, scientists from CNRS, Institut Curie and Sorbonne Université have been able to act physically on chromosomes in living cells. By subjecting the chromosomes to different forces using magnets, they discovered that chromosomes are in fact very fluid – almost liquid – outside cell division phases. This study is published in Science on July 29, 2022.01/08/2022
Scientific events
The trans-Golgi network (TGN) is the central sorting station of the secretory pathway, where cargo proteins are packaged into different transport carriers for export to their respective destination. Despite its fundamental importance in maintaining cellular homeostasis and function, how secretory cargoes are sorted and specifically packaged int nascent transport carriers at the TG
Kidney tubulogenesis requires the coordination of multiple cellular processes. Characterizing the dynamic cellular events underlying tubule organization is thus critical to fully understand kidney tubulogenesis and to identify the cellular causes of kidney diseases. Focusing on non-ciliary roles of an intracellular transport complex involved in polycystic kidney disease (the Intra
All scientific events
17 May
2023
Seminar Cell Biology Series
14h-23h
The kinase Misshapen/MAP4K4 coordinates collective cell migrations
Collective cell migration is a crucial process during development, wound healing, and metastasis that requires coordinated cell behaviors at the group level. We identified MAP4K4 as a conserved regulator of collective cell migration. By studying Drosophila egg chamber border cells, we found that Misshapen, the MAP4K4 ortholog, coordinates protrusion formation and actomyosin contractility to promot
17 Apr
2023
Seminar Cell Biology Series
14h-23h
Cell Biological mechanisms mediating optimal immunosurveillance
Healthy immunity requires that T lymphocytes (T cells) perform immunosurveillance. To execute this function, T cells must (1) infiltrate complex tissues, (2) identify antigenic signatures of disease via specialized intercellular junctions termed immunological synapses, and (3) amplify antigen-triggered signaling at the synapse. The regulation of each of these processes is crucial for mounting an e
9 Dec
2022
Seminar Cell Biology Series
11h-23h
Sorting of Secretory Proteins at the trans-Golgi Network
The trans-Golgi network (TGN) is the central sorting station of the secretory pathway, where cargo proteins are packaged into different transport carriers for export to their respective destination. Despite its fundamental importance in maintaining cellular homeostasis and function, how secretory cargoes are sorted and specifically packaged int nascent transport carriers at the TG
2 Dec
2022
Seminar Cell Biology Series
11h-23h
Dynamics and effects of mammalian DNA methylation
DNA methylation is essential to development and cellular physiology in mammals. Faulty DNA methylation is frequently observed in human diseases like cancer and neurological disorders. Molecularly, this epigenetic mark is linked to other chromatin modifications and it regulates key genomic processes, including transcription and splicing.
We have designed a CRISPR screen in mouse ES cells to iden
We have designed a CRISPR screen in mouse ES cells to iden
25 Nov
2022
Seminar Cell Biology Series
11h-23h
Controlled furrow constriction in cytokinesis ensures lumen size maintenance in tubular epithelia
Kidney tubulogenesis requires the coordination of multiple cellular processes. Characterizing the dynamic cellular events underlying tubule organization is thus critical to fully understand kidney tubulogenesis and to identify the cellular causes of kidney diseases. Focusing on non-ciliary roles of an intracellular transport complex involved in polycystic kidney disease (the Intra
Job offers
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Post-doctorat en biologie cellulaire (H/F)Le Centre de recherche de l’Institut Curie
L'Institut Curie est un acteur majeur de la recherche et de la lutte contre le cancer. Il est constitué d'un hôpital et d'un Centre de recherche de plus de 1000 collaborateurs avec une forte représentativité internationale.
L’objectif du Centre de recherche de l’institut Curie est de développer la recherche fondamentale et d’utiliser les connaissances produites pour améliorer le diagnostic, le pronostic, la thérapeutique des cancers dans le cadre du continuum entre la recherche fondamentale et l’innovation au service du malade.
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Postdoctoral Position in Cell Biology (M/F)Institut Curie Research Center
Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international representativeness. The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.