Unit
Cell Biology and Cancer (UMR144)
Thematic areas of research:
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Unit
FRANCK PEREZ / RENATA BASTO
Cell Biology and Cancer (UMR144)
The mission of this unit is to understand the biogenesis of the cell compartments and the molecular mechanisms that govern normal cellular functions.
The main research themes of the unit include:
- Transport pathways between compartments,
- The dynamics of the actin- and microtubule-based cytoskeletons,
- Three-dimensional structures of molecular motors,
- Mechanisms of cell division and cell migration,
- The mechanisms involved in establishing the polarity of epithelia and their differentiation,
- Signalling pathways associated with tumour progression in several mouse models and human tumours,
- Regulation of adhesive systems during morphogenesis and development.
Teams
Key figures
165
members in 2020
34
PhD students in 2020
82
publications in 2020
Key publications
All publications
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Force Generation by Myosin Motors: A Structural PerspectiveChemical Reviews
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RAB6 and microtubules restrict protein secretion to focal adhesionsJournal of Cell Biology
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News
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Congratulations to Dr. Alexandre Baffet, 2023 winner of the Fondation Bettencourt Schueller Impulscience programDr. Alexandre Baffet, head of research team at the Institut Curie, is one of 7 new beneficiaries of the Impulscience research support program. This 2.3 million euro grant will enable him to learn more about brain stem cells, especially in the human neocortex.22/11/2023 -
Comment deux structures cellulaires s’allient pour donner le feu vert à la dissémination tumorale ?Les mécanismes de la dissémination tumorale recèlent encore de nombreux secrets. Dans le cadre de l’étude des processus métastatiques, les chercheurs de l’Institut Curie, de l’Inserm et du CNRS ont identifié pour la première fois des interrelations dynamiques spécifiques aux cellules tumorales impliquant deux structures : les cavéoles et les invadopodes. Publiés dans Nature Cell Biology le 30 octobre 2023, ces résultats ouvrent la voie au développement de nouvelles cibles thérapeutiques pour le traitement des cancers.30/10/2023 -
CATCHFIRE: An innovative tool to control the private lives of cells and view them via fluorescenceResearchers from Institut Curie, the CNRS, Sorbonne University and ENS-PSL have just developed an innovative molecular tool. Known as CATCHFIRE, it lets you not only control the closeness of two proteins, but also view their proximity. These multi-disciplinary efforts offer a number of applications for study of basic biological processes, but also in biomedicine, for genetic and metabolic diseases for example, or in the field of cell therapy for cancer treatment. These results are published on August 28, 2023, in Nature Methods.06/09/2023 -
Structure of Resting Cardiac Myosin RevealedFor the first time ever, a team from Institut Curie has managed to observe the structure of cardiac myosin in a particular state: the sequestered state. This discovery furthers understanding of how heart muscle works and could have implications for patients with cardiomyopathy.30/06/2023 -
Cryomicroscopy: the Research Center thinks bigThe brand new Glacios Cryo-TEM™ by Thermo Fischer was received in February at Institut Curie’s Research Center, This powerful cryo-electron microscope worth over 2 million euros will enable researchers to observe proteins at unprecedented resolution. A new opportunity to understand their function and the alterations responsible for diseases, particularly cancer.17/04/2023 -
Institut Curie certified as Integrated cancer research site for the third timeFollowing a call for applications launched in April 2022, Institut Curie had its integrated cancer research site project certified by France’s Institut national du cancer (Inca). Its goal is to better understand tumor recurrences in order to better prevent, detect and treat them.20/02/2023
Scientific events
Flagella and cilia are evolutionarily conserved microtubule-based protrusions essential for cell locomotion, fluid movement and sensing of extracellular cues. Primary cilia are found at the surface of most vertebrate cells and function as cellular antennas that detect various chemical and mechanical signals, thereby playing crucial roles in intracellular signaling and development.
Flagella and cilia are evolutionarily conserved microtubule-based protrusions essential for cell locomotion, fluid movement and sensing of extracellular cues. Primary cilia are found at the surface of most vertebrate cells and function as cellular antennas that detect various chemical and mechanical signals, thereby playing crucial roles in intracellular signaling and development.
The trans-Golgi network (TGN) is the central sorting station of the secretory pathway, where cargo proteins are packaged into different transport carriers for export to their respective destination. Despite its fundamental importance in maintaining cellular homeostasis and function, how secretory cargoes are sorted and specifically packaged int nascent transport carriers at the TG
All scientific events
9 Jun
2023
Seminar Cell Biology Series
11h-13h
MiniBAR is a dual Rac and Rab effector that controls cilia length and left-right asymmetry in vivo
Flagella and cilia are evolutionarily conserved microtubule-based protrusions essential for cell locomotion, fluid movement and sensing of extracellular cues. Primary cilia are found at the surface of most vertebrate cells and function as cellular antennas that detect various chemical and mechanical signals, thereby playing crucial roles in intracellular signaling and development.
9 Jun
2023
Seminar Cell Biology Series
11h-13h
MiniBAR is a dual Rac and Rab effector that controls cilia length and left-right asymmetry in vivo
Flagella and cilia are evolutionarily conserved microtubule-based protrusions essential for cell locomotion, fluid movement and sensing of extracellular cues. Primary cilia are found at the surface of most vertebrate cells and function as cellular antennas that detect various chemical and mechanical signals, thereby playing crucial roles in intracellular signaling and development.
17 May
2023
Seminar Cell Biology Series
14h-23h
The kinase Misshapen/MAP4K4 coordinates collective cell migrations
Collective cell migration is a crucial process during development, wound healing, and metastasis that requires coordinated cell behaviors at the group level. We identified MAP4K4 as a conserved regulator of collective cell migration. By studying Drosophila egg chamber border cells, we found that Misshapen, the MAP4K4 ortholog, coordinates protrusion formation and actomyosin contractility to promot
17 Apr
2023
Seminar Cell Biology Series
14h-23h
Cell Biological mechanisms mediating optimal immunosurveillance
Healthy immunity requires that T lymphocytes (T cells) perform immunosurveillance. To execute this function, T cells must (1) infiltrate complex tissues, (2) identify antigenic signatures of disease via specialized intercellular junctions termed immunological synapses, and (3) amplify antigen-triggered signaling at the synapse. The regulation of each of these processes is crucial for mounting an e
9 Dec
2022
Seminar Cell Biology Series
11h-23h
Sorting of Secretory Proteins at the trans-Golgi Network
The trans-Golgi network (TGN) is the central sorting station of the secretory pathway, where cargo proteins are packaged into different transport carriers for export to their respective destination. Despite its fundamental importance in maintaining cellular homeostasis and function, how secretory cargoes are sorted and specifically packaged int nascent transport carriers at the TG
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