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Unit
FRANCK PEREZ / RENATA BASTO
Cell Biology and Cancer (UMR144)

The mission of this unit is to understand the biogenesis of the cell compartments and the molecular mechanisms that govern normal cellular functions.

The main research themes of the unit include:

  • Transport pathways between compartments,
  • The dynamics of the actin- and microtubule-based cytoskeletons,
  • Three-dimensional structures of molecular motors,
  • Mechanisms of cell division and cell migration,
  • The mechanisms involved in establishing the polarity of epithelia and their differentiation,
  • Signalling pathways associated with tumour progression in several mouse models and human tumours,
  • Regulation of adhesive systems during morphogenesis and development.
Key figures
165
members in 2020
34
PhD students in 2020
82
publications in 2020
Key publications
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Scientific events
31 May
2022
Seminar Cell Biology Series
11h-23h
Mechano-Immunology: Novel mechanical routes to drive inflammatory epigenomic programs
Nikhil Jain is a Birmingham Fellow working across the Institutes of Inflammation and Ageing, and the School of Chemical Engineering. Nikhil is a cell engineer who specializes in mechanobiology and developing novel bioengineering tools and techniques and combining them with cutting-edge epi-imaging, and advanced “omics” to tackle challenging questions in human h
22 Mar
2022
Seminar Cell Biology Series
11h-13h
Investigating cellular logistics with live-cell STED super-resolution microscopy
In the lab we use gene editing and live-cell super-resolution microscopy to study the mechanisms of membrane homeostasis in health and disease. To be able to image physiological molecular processes in the crowded cellular cytoplasm in living cells, we developed labelling methods for stimulated emission depletion (STED) super-resolution imaging in living cells and a pipeline for the rapid generatio
1 Feb
2022
Seminar Cell Biology Series
11h-13h
Caveolae rings form platforms for Amphiphysin2/Bin1-mediated T-tubule initiation
Caveolae have been proposed to participate in the formation of the T-tubule system in skeletal muscle but to date, mechanistic understanding of the tubulation process per se is cruelly lacking. Here, we developed a two-colour super-resolution and platinum replica correlative electron microscopy technique to visualise caveolae during critical steps of T-tubule formation in extensively differentiate
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Job offers
  • Post-doctoral fellow (H/F)
    The Institut Curie is a major player in cancer research and control. It consists of a hospital and a research center with more than 1,000 employees and a strong international presence.
    The objective of the Institut Curie Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis and treatment of cancer as part of the continuum between basic research and innovation in the service of patients.

  • Assistant ingénieur/ Ingénieur d’études (H/F)
    L'Institut Curie est un acteur majeur de la recherche et de la lutte contre le cancer. Il est composé d'un Groupe Hospitalier et d'un Centre de Recherche de plus de 1000 salariés avec une forte représentativité internationale.
    L'objectif du Centre de Recherche est de développer la recherche fondamentale et d'utiliser les connaissances produites pour améliorer le diagnostic, le pronostic et la thérapeutique des cancers dans le cadre du continuum entre recherche fondamentale et innovation au service du patient.
    L’Institut Curie est centre de référence pour le rétinoblastome (tous les patients en France atteints de ce cancer sont traités et suivis à l’Institut Curie).
  • Postdoctoral Position in Oncology (M/F) in the framework of a collaborative project on retinoblastoma
    Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international representativeness.
    The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient. It is located on 2 main sites, one in central Paris, the other in Orsay (suburb of Paris). These two sites are easily connected by public transportation with a direct RER line.
    The Institut Curie treats and follows all patients in France with retinoblastoma.
  • Postdoctoral Position (M/F) in Cell Biology – Intracellular trafficking
    Institut Curie Research Center
    Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international representativeness.
    The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient. The Institut Curie is comprised 13 outstanding Research Units covering various fields (e.g. epigenetics, immunology, cell biology, chemistry & biology, physics & biology) and 19 cutting-edge technological facilities (e.g. Live imaging, cytometry, electron microscopy, genomics, proteomics).
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