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Cell Biology and Cancer (UMR144)

The mission of this unit is to understand the biogenesis of the cell compartments and the molecular mechanisms that govern normal cellular functions.

The main research themes of the unit include:

  • Transport pathways between compartments,
  • The dynamics of the actin- and microtubule-based cytoskeletons,
  • Three-dimensional structures of molecular motors,
  • Mechanisms of cell division and cell migration,
  • The mechanisms involved in establishing the polarity of epithelia and their differentiation,
  • Signalling pathways associated with tumour progression in several mouse models and human tumours,
  • Regulation of adhesive systems during morphogenesis and development.
Key figures
members in 2020
PhD students in 2020
publications in 2020
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17 May
Seminar Cell Biology Series
The kinase Misshapen/MAP4K4 coordinates collective cell migrations
Collective cell migration is a crucial process during development, wound healing, and metastasis that requires coordinated cell behaviors at the group level. We identified MAP4K4 as a conserved regulator of collective cell migration. By studying Drosophila egg chamber border cells, we found that Misshapen, the MAP4K4 ortholog, coordinates protrusion formation and actomyosin contractility to promot
17 Apr
Seminar Cell Biology Series
Cell Biological mechanisms mediating optimal immunosurveillance
Healthy immunity requires that T lymphocytes (T cells) perform immunosurveillance. To execute this function, T cells must (1) infiltrate complex tissues, (2) identify antigenic signatures of disease via specialized intercellular junctions termed immunological synapses, and (3) amplify antigen-triggered signaling at the synapse. The regulation of each of these processes is crucial for mounting an e
25 Nov
Seminar Cell Biology Series
Controlled furrow constriction in cytokinesis ensures lumen size maintenance in tubular epithelia

Kidney tubulogenesis requires the coordination of multiple cellular processes. Characterizing the dynamic cellular events underlying tubule organization is thus critical to fully understand kidney tubulogenesis and to identify the cellular causes of kidney diseases. Focusing on non-ciliary roles of an intracellular transport complex involved in polycystic kidney disease (the Intra
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