Tenured Research Scientist CNRS
Recherche - Orsay
Spécialités / domaines
In vivo experiment,
Cell biology,
Research Center,
Cellular and Tissue Imaging,
Basic research

Research interests

My main research interest is the role of the regulation of the microtubule cytoskeleton by posttranslational modifications. I focus mostly on tubulin polyglutamylation, the modification mostly enriched in neurons, and its impact on the regulation of neuronal function and in neurodegeneration. I have developed a number of murine models of polyglutamylation and analysed them at the organism and cellular levels. I also contribute to investigating the role of posttranslational modifications of tubulin in in vitro approaches.

Professional experience

  • Oct 2020: CNRS permanent researcher (CRCN), Institut Curie, Orsay, France
  • Oct 2008 – Oct 2020: non-permanent researcher with Carsten Janke, CRBM-CNRS, Montpellier, Institut Curie, Orsay, France, “Role of tubulin polyglutamylation in neurodegeneration.”
  • Oct 2006 – Sept 2008: Post-doc with Solange Desagher, IGMM-CNRS, Montpellier, France, “Role of the anti-apoptotic protein, Mcl-1 in neuronal apoptosis.”
  • Feb 2002 –Sept 2006: PhD with Etienne Schwob, IGMM-CNRS, Montpellier, France, “Checkpoint surveillance of the unperturbed DNA replication.”
  • May 2001 – Jan 2002: Master project and Research Assistant with Miles D. Houslay, Institute of Biomedical and Life Sciences, University of Glasgow, UK, “Mechanism of action of PDE4, the multienzyme cAMP-specific phosphodiesterase family.”

Grants and prize

  • AFM-Telethon, 2021-2023
  • PSL-Biogen, 2020-2023
  • Tom Wahlig Stiftung, 2020-2021
  • Association France Alzheimer, 2020-2021
  • Association Strümpell Lorrain - France, 2020-21
  • Fondation Vaincre Alzheimer Pilot Award, 2017-2018

        Forcheurs Jean-Marie Lehn 2019 prize


  • HDR (Habilitation à Diriger les Recherches), Paris Sud-Paris Saclay, France, October 2019
  • PhD of Université Montpellier II, France, September 2006
  • Master in Molecular Biology, Jagiellonian University, Kraków, Poland, April 2001
Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations
Nature Communications
Caroline Le Dour, Maria Chatzifrangkeskou, Coline Macquart, Maria M. Magiera, Cécile Peccate, Charlène Jouve, Laura Virtanen, Tiina Heliö, Katriina Aalto-Setälä, Silvia Crasto, Bruno Cadot, Déborah Cardoso, Nathalie Mougenot, Daniel Adesse, Elisa Di Pasquale, Jean-Sébastien Hulot, Pekka Taimen, Carsten Janke, Antoine Muchir