Unit
Genome Integrity, RNA and Cancer (UMR3348)
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STEPHAN VAGNER / SARAH LAMBERT
Genome Integrity, RNA and Cancer (UMR3348)
The research conducted at the « Genome Integrity, RNA and Cancer » Unit explores multiple aspects of genome dynamics that integrate RNA biology in the context of genome maintenance and expression in normal and pathological situations, including cancer.
Teams
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25
km from Paris
25
nationalities since 2015
25
INTERNATIONAL EVENTS ORGANISED
Key publications
All publications
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The plasticity of mRNA translation during cancer progression and therapy resistanceNature Reviews Cancer
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Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1Nature Communications
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Cytidine Deaminase Deficiency Reveals New Therapeutic Opportunities against CancerClinical Cancer Research
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News
All news
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New results for better treatment of T-cell acute lymphoblastic leukemiaT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive type of blood cancer characterized by the proliferation of T-lymphocyte precursors that are abnormally arrested in their differentiation. A new Institut Curie study led by Drs. Christine Tran Quang and Jacques Ghysdael, researchers in the RNA Biology, Signalling and Cancer team of the Genome Integrity, RNA and Cancer unit (CNRS UMR 3348 / Université Paris-Saclay), characterizes the anti-leukemic effects of an immunotherapy targeting the T-cell antigen receptor. These results, published in Blood on May 23, 2024, pave the way for the development of new therapies.15/07/2024 -
World Triple Negative Breast Cancer Day: innovation to cure more womenWorld Triple Negative Breast Cancer Day, held on March 3rd, is a reminder that triple-negative breast cancers remain the most difficult to treat, and that only innovation and dynamic research can bring hope of curing more patients.01/03/2024 -
Dr. Albertas Navickas, winner of the prix Ruban Rose Avenir 2023Dr. Albertas Navickas, head of the RNA, Tumor Microenvironment and Metastasis team in the Genome integrity, RNA and Cancer unit (CNRS UMR3348/University Paris-Saclay), was recognized by the Ruban Rose association for his promising project on communication between cancer cells of the breast and the cells of the lungs.24/10/2023 -
New major players in the protection of DNA replication forks are identifiedIn an article published on March 2, 2023, in the journal Molecular Cell, the team led by Sarah Lambert, in collaboration with researchers from the Institute for Integrative Biology of the Cell, revealed a mechanism that ensures the integrity of DNA replication forks. Based on the combination of RNA and the end-joining factor Ku, it represents a potential new therapeutic target to fight cancerous cells.13/03/2023 -
Three research projects at Institut Curie financed by the ERC Synergy GrantThree projects at Institut Curie are laureate of the highly selective and prestigious Synergy Grant 2022 program, awarded by the European Research Council. These three grants, for an amount of 10 million euros each, shine a light on Institut Curie’s excellence and its teams in cellular biology. A breakthrough field to further the fight against cancer.28/10/2022 -
Carsten Janke awarded an ERC Advanced GrantLong-neglected, research on post-translational modifications of microtubules is now a promising field, thanks in particular to Carsten Janke, a world expert in this area. His excellence in this discipline and the hopes placed in his research have been recognized by the European Research Council (ERC).12/08/2022
Scientific events
All scientific events
21 Oct
2024
Seminar
11h-12h
'From genome-wide analyses to a novel factor implicated in epigenetic inheritance: Unraveling the mechanisms of heterochromatin regulation'
"Eterochromatin, a specialized type of chromatin, is crucial for gene regulation and genome stability. While we understand some of the structural and enzymatic components involved in heterochromatin formation, a complete picture of the underlying pathways remains elusive. To address this, we developed a systematic approach to identify factors involved in heterochromatin silencing in Schizosac
27 Sep
2024
Seminar
11h-12h
RNA-binding proteins in cancer: lessons from CSDE1
"RNA-binding proteins (RBPs) modulate all aspects of post-transcriptional gene expression and are increasingly recognized as essential for cancer cell adaptation, reprogramming and stress survival. We aim to identify novel vulnerabilities of metastatic cells that could be harnessed for cancer treatment. My talk will focus on the RNA-binding protein UNR/CSDE1, a protein conserved from flies to
20 Sep
2024
Seminar
11h-23h
In situ structural mechanism of Epothilone B-induced CNS axon regeneration
Neurons in the Central Nervous System (CNS) often struggle to regenerate following traumatic brain injury, with the underlying molecular mechanisms largely unknown. We developed a cryo-electron tomography/light microscopy pipeline to simulate axonal injury and regeneration on electron microscope (EM) grids. I will discuss how Epothilone B (EpoB), a chemical compound, alters intracellular organizat
10 Jun
2024
Seminar
14h-23h
Cracking the 9+2 Code of Motile Cilia
The axoneme of motile cilia is the largest macromolecular machine of eukaryotic cells. In humans, impaired axoneme function causes a range of ciliopathies. In most motile cilia, the axoneme has a 9+2 architecture in which nine doublet microtubules surround a central pair of singlet microtubules. Use single-particle cryo-EM, we could visualize and build atomic models of the native repeating structu
26 Apr
2024
Seminar
11h-12h
On the multiple roads to cell fate decisions: Integrating transcription factors into RNA-regulatory networks
While the current view states that Transcription Factors (TFs) act on DNA regulatory elements to deploy precise gene programs, an emerging concept proposes that TFs also bind RNA and regulate splicing to promote molecular and cellular diversity. Yet, how the RNA regulatory functions of TFs contribute to their key role in cell fates remains puzzling. From in vitro interaction to tissue development,