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Unit
STEPHAN VAGNER / SARAH LAMBERT
Genome Integrity, RNA and Cancer (UMR3348)

The research conducted at the « Genome Integrity, RNA and Cancer » Unit explores multiple aspects of genome dynamics that integrate RNA biology in the context of genome maintenance and expression in normal and pathological situations, including cancer.

Key figures
25
km from Paris
25
nationalities since 2015
25
INTERNATIONAL EVENTS ORGANISED
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Scientific events
15 Sep
2023
Orsay seminar series
11h-23h
Exploiting self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress
I will present two discoveries from my team dealing with precision medicine approaches and possibilities. The first part deals with widely used genotoxic cancer therapy, such as irradiation. These modalities operate through extensive induction of DNA breaks, yet cancer cells frequently display resistance to such interventions. Intriguingly, studies following the dynamics of radiation-induced DNA l
11 Jul
2023
Institutional seminar "Mayent - Rothschild"
11h-23h
Melanoma metastatic niche formation: extracellular vesicles, miRNA, immune, CAF and more
Melanoma initiate at the epidermis and become metastatic once invade into the dermis. We present mutation independent trigger of melanoma switch into the invasive dermal phenotype from the radial dermal growth. We further showed how melanoma cells shape the tumor microenvironment by the trafficking of miRNA via large extracellular vesicles.  In recent work we found melanoma interactions with
3 Jul
2023
Orsay seminar series
11h-23h
Microtubule Methylation: The Second Language of Chromatin “Readers, Writers and Erasers
Dr. Cheryl Lyn Walker directs the Center for Precision Environmental Health at Baylor College of Medicine, where she holds the Alkek Presidential Chair in Environmental Health.  Her research focuses on the epigenetic machinery responsible for “reading, writing and erasing” histone modifications, and the newly discovered role for this machinery outside the nucleus, where it acts di
15 Dec
2022
Seminar
11h-12h
Advances on Human Topoisomerases IIIA and IIIB, the Most Ancestral and Least Known Topoisomerases
Human cells encode 6 topoisomerases to regulate the topology of nucleic acids. While yeast has only one Top3, mammals encode two Type IA topoisomerases: topoisomerase III alpha (TOP3A) and topoisomerase III beta (TOP3B). We will review the importance of these two enzymes and present new insights on their biochemistry, molecular structure, and biological functions for replicating the nuclear and mi
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