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Presentation

Part of the team (New biomarkers for phenotypic imaging) is dedicated to the design and/or evaluation of innovative radiotracers for molecular imaging by Positron Emission Tomography (PET), targeting key processes in cancerology. The objective is twofold: to better understand the mechanisms underlying the development of cancer and response or resistance to treatment, and to optimise therapeutic management through the identification of phenotypes that facilitate personalised medicine.

The other part (Integrated Radiomics for Precision Medicine) exploits PET imaging biomarkers, but also CT and MRI, and combines them with other biomarkers (clinical, pathological, blood, genomic) to establish a specific disease profile with prognostic or predictive value. The models developed should also improve our understanding of the processes associated with cancer.

Publications

Life of the team

  • October 2024 : Organisation  of the 1rst international workshop, Empower2024, dedicated to research integrating the different facets of the human person (whole person research) at Institut Pascal of Université Paris-Saclay.
  • September 2024 : The trainees we welcome this year, Ghada Lemoudda, Hugo Lopez et Saad Kinan all successfully defended their internship dissertations and obtained their Master 2 and engineering school diplomas.
  • September 2024 : Nous avons le plaisir d'accueil un nouveau doctorant, Julien Mégrourèche, physicien médical canadien, qui rejoint le laboratoire pour faire une thèse sous la direction de Ludovic de Marzi, sur la radiothérapie innovante combinant fractionnement spatial et fractionnement temporel de la dose.
  • June 2024 : Ludovic de Marzi HDR Defense, entitled "Spatial and temporal optimization of radiotherapy treatments".
  • May 2024 :  Nicolas Captier scientific Thesis defense, entitled "Multimodal and integrative analysis of radiological, pathological, and transcriptomic data for the prediction of immunotherapy outcome in Non-Small Cell Lung Cancer".
  • May 2024 : Louis Rebaud scientific Thesis defense, entitled "Whole-body / total-body biomarkers in PET imaging".
  • April 2024 : Fanny Orlhac HDR Defense, entitled "From extracting radiomic biomarkers to developing models for precision medicine".
  • March 2024 : Since the beginning of the year, we've had the pleasure of welcoming new colleagues for their Master 2 internships (Ghada Lemoudda et Hugo Lopez), as engineer (Charlotte Loisel), or as PhD student (Paul Steinmetz). 
  • January 2024 : Fahad Khalid Thesis defense, entitled "Magnetic Resonance Imaging and Genomic Mutation in Diffuse intrinsic pontine glioma : Machine Learning Approaches for a Comprehensive Analysis“.

 

  • December 2023 : Jérémie Calais Thesis Defense, entitled s'intitulant "Théranostique ciblant le PSMA : de la recherche clinique à la norme de soins standard" 
  • December 2023 :  Organization of the first LITO Open House for employees of the Institut Curie research center and hospital. The aim is to give them a better understanding of our activities.
  • November2023 : Thibault Escobar, Thesis Defense, entitled « Développement de modèles interprétables par des approches d’apprentissage à partir d'images TEP, TDM, et IRM pour la prise en charge de patients atteints de cancer ».
  • October 2023 :  Paul Steinmetz joins LITO as a PhD student working on the AI.DREAM project funded by BPI France and led by GE Healthcare. He will develop generic methods to help characterize the robustness of learning-based algorithms and predict their applicability to new data.
  • October 2023 : Arnaud Beddok Thesis Defense, entitled "Multimodal Imaging-guided Optimization of Patient Selection and Treatment Plans for Reirradiation of Recurrent Head and Neck Cancer".
  • September 2023 : Benjamin Nicaise et Mathilde Droguet ont brillamment validé leurs stages M2 au LITO, et ainsi contribué à la radiomique en imagerie TEP PSMA dans le cancer de la prostate, et à l'évaluation de la segmentation automatique par deep learning d'IRM mammaires de patientes atteintes de cancer du sein et traitées par chimiothérapie néoadjuvante.
  • June 2023 : Participation of 6 laboratory members at the World Congress of Nuclear Medicine and Molecular Imaging (SNMMI 2023) in Chicago to present their contributions to 11 original developments.
  • May 2023 : Kibrom Girum has just been awarded the Alavi-Mandell Prize by the American Society of Nuclear Medicine and Molecular Imaging (SNMMI) for the paper « 18F-FDG PET Maximum-Intensity Projections and Artificial Intelligence: A Win-Win Combination to Easily Measure Prognostic Biomarkers in DLBCL Patients » https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9730929
  • March 2023 : Many new colleagues: Trung Kien Bui (PhD student), Mohamed Ourahou (Master2), Mathilde Droguet (Master2), Benjamin Nicaise (Master2) and Adam Diakite (engineer) have recently joined the laboratory to work on new projects.

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